{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:57:17Z","timestamp":1788116237351,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for secondary acute myeloid leukemia (sAML). This study compared haploidentical donor (Haplo), matched sibling donor (MSD), and matched unrelated donor (MUD) HSCT in patients with sAML in first complete remission (CR1). Data from 3862 patients (Haplo\u2009=\u2009643, MSD\u2009=\u2009715, MUD\u2009=\u20092504) transplanted between 2010 and 2022 were analyzed, with a median follow\u2010up of 3.3\u2009years. Groups differed in patient and donor age, conditioning regimen, stem cell source, and graft\u2010versus\u2010host disease (GVHD) prophylaxis. Multivariate analysis showed that MSD\u2010HSCT had a higher relapse risk than Haplo\u2010HSCT (hazard ratio [HR]: 1.64) but lower non\u2010relapse mortality (NRM, HR: 0.32) and acute GVHD risk (HR: 0.54 for grade II\u2013IV), leading to an overall survival (OS) benefit (HR: 0.76). MUD\u2010HSCT had lower NRM than Haplo\u2010HSCT (HR: 0.63) but there were no significant differences in OS or GVHD risk. Donor type did not impact leukemia\u2010free survival (LFS) or GVHD\u2010free and relapse\u2010free survival (GRFS). Adverse cytogenetics and reduced\u2010intensity conditioning were associated with increased relapse risk, while lower Karnofsky scores, older age, and adverse cytogenetics independently predicted worse NRM, LFS, OS, and GRFS outcomes. Female\u2010to\u2010male donor\u2010recipient pairs had an increased risk of chronic GVHD. In this registry\u2010based analysis, MSD offered the best outcomes for sAML in CR1. Haplo\u2010HSCT was comparable to MUD\u2010HSCT, despite a higher NRM, and achieved long\u2010term disease control in 60% of patients due to a low relapse incidence. In the absence of an MSD, both Haplo and MUD are viable alternatives.<\/jats:p>","DOI":"10.1002\/ajh.70164","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T22:10:12Z","timestamp":1765059012000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Non\u2010T\u2010Depleted Haploidentical Transplantation Compared to Allogeneic Transplantation From Matched Siblings or Unrelated Donors in Patients With Secondary\n                    <scp>AML<\/scp>\n                    in First Complete Remission: A Study From the\n                    <scp>ALWP<\/scp>\n                    \/\n                    <scp>EBMT<\/scp>"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"first","affiliation":[{"name":"Division of Hematology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-1205","authenticated-orcid":false,"given":"Sarah","family":"Kayser","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allain Thibeault","family":"Ferhat","sequence":"additional","affiliation":[{"name":"EBMT Paris Study Office; Department of Haematology Saint Antoine Hospital; INSERM UMR 938, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"University Hospital Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Eder","sequence":"additional","affiliation":[{"name":"Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Saint\u2010Louis Hospital, BMT Unit  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation &amp; Therapie Cellulaire  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schroeder","sequence":"additional","affiliation":[{"name":"University Hospital|Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Labussi\u00e8re\u2010Wallet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon Sud  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Busca","sequence":"additional","affiliation":[{"name":"SS Trapianto di Cellule Staminali  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Hopital Haut\u2010Leveque  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Gedde\u2010Dahl","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-7502","authenticated-orcid":false,"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University of Milan and Azienda Socio\u2010Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude Eric","family":"Bulabois","sequence":"additional","affiliation":[{"name":"CHU Grenoble Alpes\u2014Universit\u00e9 Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-131X","authenticated-orcid":false,"given":"Gesine","family":"Bug","sequence":"additional","affiliation":[{"name":"Goethe University  Frankfurt Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-4997","authenticated-orcid":false,"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology Division, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eolia","family":"Brissot","sequence":"additional","affiliation":[{"name":"Service D'h\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, H\u00f4pital Saint\u2010Antoine, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin","family":"Savani","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"EBMT Paris Study Office; 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