{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:56:38Z","timestamp":1788371798054,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 DA056793"],"award-info":[{"award-number":["DP1 DA056793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002369"],"award-info":[{"award-number":["UL1TR002369"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Iron deficiency anemia (IDA) is prevalent in pregnancy, yet oral iron therapies are associated with poor adherence and many intravenous (IV) iron formulations require multiple doses for treatment. Ferric derisomaltose (FDI) is a newer IV iron formulation that is safe and efficacious in non\u2010pregnant individuals, yet pregnancy data is lacking. We evaluated the safety, efficacy, and maternal and neonatal outcomes associated with a single 1000\u2009mg IV dose of FDI in pregnant individuals with IDA. We conducted a prospective, single\u2010arm interventional trial of FDI administered in the second or third trimester of pregnancy from January 2024 to July 2025. The primary outcome was efficacy (hemoglobin increase of \u2265\u20091\u2009g\/dL). Secondary outcomes included safety, other hematologic parameters, patient\u2010reported quality of life, and maternal and neonatal outcomes. Among 78 participants enrolled, 75 received FDI. From baseline to delivery, mean hemoglobin increased by 1.3\u2009g\/dL, with significant improvements (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in ferritin and transferrin saturation through 6\u2009weeks postpartum. Patient\u2010reported fatigue scores improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), as did Edinburgh Postnatal Depression Scale scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). The mean FDI infusion time was 24\u2009min. Cord blood ferritin and hemoglobin values suggested enhanced neonatal iron status. No major infusion reactions or hospitalizations occurred. Minor infusion\u2010related symptoms were uncommon and self\u2010limited: chest tightness (6.7%), flushing (5.3%), mild shortness of breath (4%), urticaria (2.7%), rash (1.3%). Two patients (2.6%) did not complete the infusion due to reaction. These findings support single\u2010dose IV FDI as a safe and effective option for late\u2010pregnancy IDA, meriting further evaluation in larger controlled trials.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70190","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T08:51:06Z","timestamp":1767343866000},"page":"669-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Single\u2010Dose Intravenous Ferric Derisomaltose for Iron Deficiency Anemia in Pregnancy"],"prefix":"10.1002","volume":"101","author":[{"given":"Ashley E.","family":"Benson","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-8202","authenticated-orcid":false,"given":"Kylee L.","family":"Martens","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-585X","authenticated-orcid":false,"given":"Monica","family":"Rincon","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Ward","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia P.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elinor L.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam K.","family":"Lewkowitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Warren Alpert Medical School at Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Methodius G.","family":"Tuuli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Warren Alpert Medical School at Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Shatzel","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-1935","authenticated-orcid":false,"given":"Jamie O.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Oregon Health &amp; Science University  Portland Oregon 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