{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:59:27Z","timestamp":1778630367793,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adult patients with immune thrombocytopenia (ITP) have an increased risk of venous thrombosis as compared to the general population. The management of ITP in the context of anticoagulation is challenging. We conducted an observational study in the prospective, multicenter, national CARMEN\u2010France registry. Adult patients with newly diagnosed ITP between June 2013 and May 2022 were selected. We assessed the cumulative incidence of venous thrombosis during follow\u2010up with death as a competing event, described these events, and assessed patient outcomes depending on management strategies, with a focus on thromboses that occurred during treatment with thrombopoietin receptor agonists (TPO\u2010RA). Among the 1303 patients selected for this study, 53 experienced venous thrombosis. The cumulative incidence of venous thrombosis was 2.6% (95% CI: 1.8\u20133.7) at 1\u2009year and 8.6% (95% CI: 5.8\u201312.0) at 5\u2009years. In patients exposed to TPO\u2010RA, the cumulative incidence was 9.3% (95% CI: 6.2\u201313.2) and 13.4% (95% CI: 8.6\u201319.2) at 1 and 5\u2009years of exposure, respectively. Patients who experienced thrombosis were older, had more frequently a history of venous thrombosis and secondary ITP, a more severe ITP, and were more frequently treated with TPO\u2010RAs. Twenty (37.7%) of the 53 events were atypical, including five cerebral venous thromboses. Four patients died, and seven experienced major bleeding. The analysis of different managements of ITP after the thrombotic event suggested that the safest strategy was to promptly control ITP to enable early anticoagulation, including using TPO\u2010RAs. Long\u2010term anticoagulation therapy should be considered in patients treated with TPO\u2010RAs and persistent risk factors for thrombosis.<\/jats:p>","DOI":"10.1002\/ajh.70192","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:41:35Z","timestamp":1767872495000},"page":"456-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence, Characteristics, and Management of Venous Thrombosis in Adult Patients With Immune Thrombocytopenia: Results From the Multicenter, Prospective Registry CARMEN\u2010France"],"prefix":"10.1002","volume":"101","author":[{"given":"Fran\u00e7ois","family":"Therme","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Francois","family":"Viallard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Rueter","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center 1436 Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-9238","authenticated-orcid":false,"given":"Thibault","family":"Comont","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Toulouse University Institute for Cancer (IUCT\u2010Oncopole)  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Cheze","sequence":"additional","affiliation":[{"name":"Department of Hematology Caen University Hospital  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Audia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dijon University Hospital  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Ebbo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Marseille University Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-1434","authenticated-orcid":false,"given":"Matthieu","family":"Mahevas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henri Mondor University Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Terriou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Lille University Hospital  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quitterie","family":"Reynaud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Lyon University Hospital, Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Yves","family":"Jeandel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nice University Hospital  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-6086","authenticated-orcid":false,"given":"Thomas","family":"Moulinet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nancy University Hospital  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Gobert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Antoine University Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Guilpain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Montpellier University Hospital  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Gourguechon","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Amiens  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailsa","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Reims University Hospital  Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ruivard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Clermont Ferrand University Hospital  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Chabbert","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center 1436 Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Bonnotte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dijon University Hospital  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Godeau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henri Mondor University Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-5873","authenticated-orcid":false,"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center 1436 Toulouse University Hospital  Toulouse France"},{"name":"Department of Clinical Pharmacology Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3420-7005","authenticated-orcid":false,"given":"Yoann","family":"Zadro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Toulouse University Hospital  Toulouse France"},{"name":"Clinical Investigation Center 1436 Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-7400","authenticated-orcid":false,"given":"Marc","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henri Mondor University Hospital, Assistance Publique\u2014H\u00f4pitaux de Paris  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-4640","authenticated-orcid":false,"given":"Guillaume","family":"Moulis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Toulouse University Hospital  Toulouse France"},{"name":"Clinical Investigation Center 1436 Toulouse University Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Carmen\u2010France Investigators Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1810479"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2020.05.018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018390"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08418.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0636-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17709"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.10.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17390"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12777"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.11.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.11.008"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001664"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000400"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12636"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03589.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000172694.85233.a8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-467068"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760528"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60959-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-748707"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2015.03.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1745168"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2016.09.016"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.03.020"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2024.06.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.11.021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.11.031"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1639655"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19069"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-185866"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24234"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102342"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14269"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12765"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507389"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211010875"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024027336"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T01:04:23Z","timestamp":1771203863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ajh.70192"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70192","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}