{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:59:37Z","timestamp":1790949577227,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fostamatinib is available in France since October 2021 for the treatment of adult chronic immune thrombocytopenia (ITP). French health authorities requested a 3\u2010year, prospective, multicenter registry to provide real\u2010world evidence about the effectiveness and safety of fostamatinib. Patients' characteristics, treatment response (ongoing exposure to fostamatinib and a platelet count \u2265\u200930\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L with no rescue in the previous 4\u2009weeks) after 3, 6, 12, and 24\u2009months (M); bleeding; fostamatinib discontinuation; adverse drug reactions (ADRs) and other events of interest have been analyzed. In total, 164 patients were included (median age: 59\u2009years; 55.5% women; 84.1% had previous bleeding; 30 had secondary ITP; 89.0% had chronic ITP). The median ITP duration was 7.2\u2009years and the median number of previous ITP treatments was 6. The response rate was 44.0% (70\/159) at M3, 41.9% (62\/148) at M6, 32.4% (44\/136) at M12 and 20.0% (21\/105) at M24. Concomitant treatment (mostly\u00a0TPO\u2010RA) was used in &gt;\u200960.0% of responders at each endpoint. The cumulative discontinuation rate at each endpoint\u00a0was, respectively, 27.0%, 44.6%, 55.9%, and 76.2%. Seventy\u2010one (43.3%) patients experienced at least one bleeding during\u00a0fostamatinib exposure; none was fatal. One hundred adverse drug reactions (8 serious) were observed in 61 (36.7%)\u00a0patients, including diarrhea in 28 (17.1%) patients, arterial hypertension in 17 (10.4%). Seven thrombosis (4.3%) and\u00a040 infections (12 serious) were reported in 25 patients (15.2%), mostly in patients with known risk factors. In conclusion,\u00a0fostamatinib in combination with TPO\u2010RA should be considered in difficult\u2010to\u2010treat ITP patients. No new safety signal was observed.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70194","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:15:37Z","timestamp":1767874537000},"page":"736-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Real\u2010World Effectiveness and Safety of Fostamatinib in Difficult\u2010to\u2010Treat Immune Thrombocytopenia Patients. A Prospective, Multicenter Registry in France"],"prefix":"10.1002","volume":"101","author":[{"given":"Guillaume","family":"Moulis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Toulouse University Hospital  Toulouse France"},{"name":"Clinical Investigation Center Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Mah\u00e9vas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Referral Center for Autoimmune Cytopenias Cr\u00e9teil University Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Viallard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pessac University Hospital, University of Bordeaux  Bordeaux 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