{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:57:53Z","timestamp":1788645473450,"version":"build-2803163510"},"reference-count":94,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Senior Fellowship (202800\/Z\/16\/Z)"],"award-info":[{"award-number":["Senior Fellowship (202800\/Z\/16\/Z)"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sickle Cell Disease (SCD) is highly prevalent in sub\u2010Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding. Due to genetic, environmental, and socioeconomic factors, the disease course differs markedly from that in high\u2010income countries. Although mortality is improving and can be further lowered with simple interventions, it remains high, especially among undiagnosed children. Genetic factors, poor healthcare infrastructure, and poverty contribute to disease severity. While recent collaborative programs like SickleInAfrica offer hope, national policies that foster the training of healthcare workers, newborn screening, and access to treatment are crucial to reducing the burden of SCD across the region.<\/jats:p>","DOI":"10.1002\/ajh.70212","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:46:21Z","timestamp":1773485181000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Epidemiology of Sickle Cell Disease in Sub\u2010Saharan Africa: Current Knowledge and Gaps to be Filled"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-2275","authenticated-orcid":false,"given":"Brigitte","family":"Ranque","sequence":"first","affiliation":[{"name":"Internal Medicine Department, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique Des H\u00f4pitaux de Paris, Initiatives IdEx Globule Rouge D'Excellence (InIdex GR\u2010Ex) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-0227","authenticated-orcid":false,"given":"Leon","family":"Tshilolo","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale 1 Health, Kinshasa; Pediatrics Department Universit\u00e9 Officielle de Mbujimayi  Mbujimayi Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-2382","authenticated-orcid":false,"given":"Thomas N.","family":"Williams","sequence":"additional","affiliation":[{"name":"KEMRI\u2010Wellcome Trust Research Programme, Kilifi, Kenya Institute of Global Health Innovation, Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"issue":"4","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/ejh.12607","article-title":"G6PD Deficiency and Absence of \u03b1\u2010Thalassemia Increase the Risk for Cerebral Vasculopathy in Children With Sickle Cell Anemia","volume":"96","author":"Joly P.","year":"2016","journal-title":"European Journal of Haematology"},{"issue":"3","key":"e_1_2_14_3_1","first-page":"202","article-title":"Sickle Cell Anemia: Beta s\u2010Gene\u2010Cluster Haplotypes as Prognostic Indicators of Vital Organ Failure","volume":"28","author":"Powars D. 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