{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:45:29Z","timestamp":1788223529201,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010mutated acute myeloid leukemia (AML); however, real\u2010world data in elderly patients (\u2265\u200960\u2009years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009194) versus IC alone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009371) in 565 patients with\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010mutated AML aged \u2265\u200960\u2009years (median age 67.5\u2009years; 35.6% \u2265\u200970\u2009years). MIDO+IC was associated with lower day\u201060 early death (8.2% vs. 21.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and higher composite complete remission (CRc) rates (78.9% vs. 63.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). After a median follow\u2010up of 46.0\u2009months, median overall survival (OS) was 24.2\u2009months for MIDO+IC versus 8.7\u2009months for IC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), with 5\u2010year OS rates of 40.6% vs. 12.9%, respectively. Event\u2010free survival (EFS; median 13.5 vs. 4.6\u2009months; 5\u2010year EFS: 36.0% vs. 10.1%) and relapse\u2010free survival (RFS; median 20.2 vs. 8.0\u2009months; 5\u2010year RFS: 45.4% vs. 15.7%) were also significantly improved (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The 5\u2010year cumulative incidence of relapse was lower with MIDO+IC (47.8% vs. 67.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In multivariate analyses, midostaurin was an independent favorable prognostic factor for CRc (aOR 1.97 [95% CI: 1.29\u20132.98]), OS (aHR 0.46 [95% CI: 0.36\u20130.58]), EFS (aHR 0.49 [95% CI: 0.39\u20130.60]), and RFS (aHR 0.47 [CI: 0.36\u20130.62]) (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.002). These benefits were confirmed by propensity score matching. This large real\u2010world study demonstrates that combining midostaurin with IC significantly improves remission rates and survival outcomes in elderly patients with\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010mutated AML, supporting its consideration in this population.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70233","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:10:01Z","timestamp":1770837001000},"page":"949-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intensive Chemotherapy With or Without Midostaurin in Adults \u2265\u200960\u2009Years Old With\n                    <scp>FLT3<\/scp>\n                    \u2010Mutated\n                    <scp>AML<\/scp>\n                    : A\n                    <scp>FILO<\/scp>\n                    \u2010\n                    <scp>DATAML<\/scp>\n                    \u2010\n                    <scp>PETHEMA<\/scp>\n                    Real\u2010World Study"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-575X","authenticated-orcid":false,"given":"Gaspar","family":"Aspas Requena","sequence":"first","affiliation":[{"name":"Montpellier University Hospital Service d'H\u00e9matologie Clinique  Montpellier France"},{"name":"University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3275-5593","authenticated-orcid":false,"given":"Pau","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe Servicio de Hematolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-5271","authenticated-orcid":false,"given":"Emilie","family":"B\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Public Health Toulouse University Hospital  Toulouse France"},{"name":"CERPOP, Inserm University Toulouse III Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-2781","authenticated-orcid":false,"given":"Sarah","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Toulouse University Hospital, Institut Universitaire du Cancer de Toulouse\u2013Oncopole, Service d'H\u00e9matologie Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-8540","authenticated-orcid":false,"given":"Rebeca","family":"Rodr\u00edguez\u2010Veiga","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe Servicio de Hematolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine","family":"Simand","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie Strasbourg Europe (ICANS) D\u00e9partement d'H\u00e9matologie  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6930-8059","authenticated-orcid":false,"given":"Laura","family":"Torres","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe Servicio de Hematolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-6686","authenticated-orcid":false,"given":"Pierre","family":"Peterlin","sequence":"additional","affiliation":[{"name":"Hematology Department Nantes University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-1649","authenticated-orcid":false,"given":"Mar","family":"Tormo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Servicio de Hematolog\u00eda Biomedical Research Institute INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-870X","authenticated-orcid":false,"given":"Rudy","family":"Birsen","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique, H\u00f4pital Cochin\u2013Port Royal (AP\u2010HP), Institut Cochin Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-1208","authenticated-orcid":false,"given":"Juan Miguel","family":"Bergua\u2010Burgues","sequence":"additional","affiliation":[{"name":"Hospital San Pedro de Alc\u00e1ntara Servicio de Hematolog\u00eda  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-8721","authenticated-orcid":false,"given":"Emmanuelle","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Saint\u2010\u00c9tienne Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Bernal del Castillo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias Servicio de Hematolog\u00eda  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-7654","authenticated-orcid":false,"given":"Martin","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Grenoble\u2010Alpes Service d'H\u00e9matologie  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gil","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Alicante Servicio de Hematolog\u00eda  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Contejean","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Annecy Genevois Service d'H\u00e9matologie Clinique  Epagny Metz\u2010Tessy (Annecy) France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-6733","authenticated-orcid":false,"given":"Eduardo","family":"Rodr\u00edguez\u2010Arbol\u00ed","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen del Roc\u00edo, Servicio de Hematolog\u00eda, Instituto de Biomedicina de Sevilla (IBiS\/CSIC) University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-0186","authenticated-orcid":false,"given":"Corentin","family":"Orvain","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie CHU d'Angers  Angers France"},{"name":"CRCINA, Inserm, Universit\u00e9 d'Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8891-5262","authenticated-orcid":false,"given":"Carlos","family":"Rodr\u00edguez\u2010Medina","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr. Negr\u00edn Servicio de Hematolog\u00eda  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-7974","authenticated-orcid":false,"given":"Lauren","family":"Veronese","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Clermont\u2010Ferrand Service de Cytog\u00e9n\u00e9tique  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-954X","authenticated-orcid":false,"given":"Maria Jose","family":"Sayas Lloris","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Peset Servicio de Hematolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-0753","authenticated-orcid":false,"given":"Eric","family":"Delabesse","sequence":"additional","affiliation":[{"name":"Toulouse University Hospital Institut Universitaire du Cancer de Toulouse\u2013Oncopole, Laboratoire d'H\u00e9matologie  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Serrano","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda, IMIBIC Universidad de C\u00f3rdoba (UCO), Servicio de Hematolog\u00eda y Hemoterapia  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7982-641X","authenticated-orcid":false,"given":"Ariane","family":"Mineur","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Bordeaux Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0959-9449","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garc\u00eda\u2010Fortes","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria Servicio de Hematolog\u00eda  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7563-580X","authenticated-orcid":false,"given":"Romain","family":"Guieze","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Clermont\u2010Ferrand Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luz","family":"Amigo","sequence":"additional","affiliation":[{"name":"Hospital Morales Meseguer Servicio de Hematolog\u00eda  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Pigneux","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Bordeaux Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-824X","authenticated-orcid":false,"given":"Lorenzo","family":"Algarra Algarra","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Albacete Servicio de Hematolog\u00eda  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-4525","authenticated-orcid":false,"given":"Christian","family":"Recher","sequence":"additional","affiliation":[{"name":"Toulouse University Hospital, Institut Universitaire du Cancer de Toulouse\u2013Oncopole, Service d'H\u00e9matologie Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3548","authenticated-orcid":false,"given":"Pierre\u2010Yves","family":"Dumas","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Bordeaux Service d'H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-4091","authenticated-orcid":false,"given":"David","family":"Mart\u00ednez\u2010Cuadr\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe Servicio de Hematolog\u00eda  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074306"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0357-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910396505"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614359"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-869453"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2373324"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281967"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009847"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254441"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.4648"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27510"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.7366"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01058-4"},{"issue":"10","key":"e_1_2_9_19_1","first-page":"2475","article-title":"Dexamethasone Added to Induction and Post\u2010Remission Therapy in Older Patients With Newly Diagnosed Acute Myeloid Leukemia: A Multicenter, Phase II Trial (DEXAML\u201002)","volume":"110","author":"Bertoli S.","year":"2025","journal-title":"Haematologica"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:36:36Z","timestamp":1776242196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ajh.70233"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70233","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"2025-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}