{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:33:43Z","timestamp":1791614023652,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170206"],"award-info":[{"award-number":["82170206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470213"],"award-info":[{"award-number":["82470213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Core binding factor acute myeloid leukemia (CBF\u2010AML) is defined by t(8;21) or inv. (16), which give rise to the\n RUNX1::RUNX1T1<\/jats:italic>\n and\n CBF\u03b2::MYH11<\/jats:italic>\n fusion genes, respectively. CBF\u2010AML is a favorable\u2010risk AML subtype, yet differences in mutation profiles, measurable residual disease (MRD) response, and relapse risk may warrant tailored treatment approaches. We reviewed adult AML patients treated at five transplant centers across China and identified 825 de novo CBF\u2010AML cases, of which 779 met our eligibility criteria: 536 harbored the\n RUNX1::RUNX1T1<\/jats:italic>\n fusion and 243 the\n CBF\u03b2::MYH11<\/jats:italic>\n fusion. The 3\u2010year overall survival (OS) was 80.6% for\n RUNX1::RUNX1T1<\/jats:italic>\n and 90.2% for\n CBF\u03b2::MYH11<\/jats:italic>\n cases (\n p<\/jats:italic>\n \u2009=\u20090.011). Among patients with\n RUNX1::RUNX1T1<\/jats:italic>\n , those achieving MRD negativity after two consolidation cycles (PC2) had significantly better OS than nonresponders (86.3% vs. 76.5%,\n p<\/jats:italic>\n \u2009=\u20090.008); no difference was observed for\n CBF\u03b2::MYH11<\/jats:italic>\n patients. For\n RUNX1::RUNX1T1<\/jats:italic>\n nonresponders, allogeneic hematopoietic cell transplantation (allo\u2010HCT) in first complete remission (CR1) reduced relapse (CR1\u2010HCT vs. non\u2010CR1\u2010HCT, 8.3% vs. 18.9%;\n p<\/jats:italic>\n \u2009=\u20090.024) and improved OS (CR1\u2010HCT vs. non\u2010CR1\u2010HCT vs. chemotherapy, 85.8% vs. 71.4% vs. 64.9%;\n p<\/jats:italic>\n \u2009<\u20090.001). In\n CBF\u03b2::MYH11<\/jats:italic>\n patients, deferring allo\u2010HCT until second complete remission (CR2) was associated with comparable outcomes. In\n RUNX1::RUNX1T1<\/jats:italic>\n patients, older age, elevated initial white blood cell count, lower hemoglobin, lower initial fusion transcript load, and the presence of\n FLT3\u2010ITD<\/jats:italic>\n or\n KIT<\/jats:italic>\n D816\/D822 mutations were associated with an increased likelihood of PC2 nonresponse. Based on these variables, we developed a weighted scoring system with good discrimination to identify RUNX1::RUNX1T1 patients at high risk of PC2 nonresponse.\n <\/jats:p>","DOI":"10.1002\/ajh.70237","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:30:56Z","timestamp":1771072256000},"page":"972-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differential Prognosis and Transplant Strategies in\n CBF<\/scp>\n \u2010\n AML<\/scp>\n With\n \n RUNX1<\/scp>\n ::\n RUNX1T1<\/scp>\n <\/i>\n Versus\n \n CBF\u03b2<\/scp>\n ::\n MYH11<\/scp>\n <\/i>\n Fusions"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4462-758X","authenticated-orcid":false,"given":"Jingtao","family":"Huang","sequence":"first","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3546-6820","authenticated-orcid":false,"given":"Huihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-5962","authenticated-orcid":false,"given":"Yunxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3115-2780","authenticated-orcid":false,"given":"Yi","family":"Xia","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7931-8401","authenticated-orcid":false,"given":"Yuqing","family":"Tu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou 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National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0334-4327","authenticated-orcid":false,"given":"Han","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-2632","authenticated-orcid":false,"given":"Zengkai","family":"Pan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3887-6496","authenticated-orcid":false,"given":"Chuanhe","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0129-5641","authenticated-orcid":false,"given":"Luxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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