{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:38:19Z","timestamp":1773758299446,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18ek0510023h0002"],"award-info":[{"award-number":["18ek0510023h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Using data from a nationwide Japanese registry, we evaluated the impact of the total body irradiation (TBI) dose in reduced\u2010intensity conditioning (RIC) for allogeneic hematopoietic cell transplantation (allo\u2010HCT) in patients with acute myeloid leukemia (AML). Adults undergoing their first allo\u2010HCT with RIC between 2010 and 2021 were classified into three groups: non\u2010TBI, low\u2010TBI (2 to &lt;\u20094\u2009Gy), or moderate\u2010TBI (4\u20138\u2009Gy). Outcomes were analyzed separately for patients in complete remission (CR,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091949) and those in the non\u2010CR group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091484). Non\u2010TBI was associated with higher overall mortality than low\u2010TBI (hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.03\u20131.56 in CR; HR, 1.19; 95% CI, 1.00\u20131.42 in non\u2010CR). Moderate\u2010TBI showed no significant difference in overall mortality compared to low\u2010TBI (HR, 0.96; 95% CI, 0.80\u20131.15 in CR; HR, 0.89; 95% CI, 0.77\u20131.05 in non\u2010CR). Among patients in the CR group with matched sibling donors, moderate\u2010TBI reduced overall mortality (HR, 0.33; 95% CI, 0.17\u20130.64) and relapse (HR, 0.29; 95% CI, 0.12\u20130.69). In cord blood transplantation, non\u2010TBI increased relapse in CR (HR, 2.73; 95% CI, 1.48\u20135.06) and overall mortality in non\u2010CR (HR, 1.62; 95% CI, 1.19\u20132.19). In haploidentical transplants, non\u2010TBI increased relapse (HR, 5.52; 95% CI, 1.72\u201317.72 in CR; HR, 1.54; 95% CI, 1.04\u20132.30 in non\u2010CR). The incidence of secondary primary malignancies did not differ according to the use or dose of TBI. In conclusion, adding low\u2010 or moderate\u2010TBI to RIC may improve disease control and survival without increasing non\u2010relapse mortality.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70265","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:39:26Z","timestamp":1772984366000},"page":"746-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Total Body Irradiation Dose in Reduced\u2010Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-8808","authenticated-orcid":false,"given":"Shohei","family":"Mizuno","sequence":"first","affiliation":[{"name":"Aichi Medical University School of Medicine  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-9976","authenticated-orcid":false,"given":"Akiyoshi","family":"Takami","sequence":"additional","affiliation":[{"name":"Aichi Medical University School of Medicine  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaito","family":"Harada","sequence":"additional","affiliation":[{"name":"Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Masuko","sequence":"additional","affiliation":[{"name":"Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Nakasone","sequence":"additional","affiliation":[{"name":"Jichi Medical University Saitama Medical Center  Saitama Japan"},{"name":"Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Toubai","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Doki","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Hyogo Medical University Hospital  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-0823","authenticated-orcid":false,"given":"Makoto","family":"Onizuka","sequence":"additional","affiliation":[{"name":"Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigesaburo","family":"Miyakoshi","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Katayama","sequence":"additional","affiliation":[{"name":"Hiroshima Red Cross Hospital &amp; Atomic\u2010Bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Toranomon Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Eto","sequence":"additional","affiliation":[{"name":"Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Osaka International Cancer Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Asada","sequence":"additional","affiliation":[{"name":"Okayama University Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Anjo Kosei Hospital  Anjo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Kanda","sequence":"additional","affiliation":[{"name":"Jichi Medical University Saitama Medical Center  Saitama Japan"},{"name":"Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Aichi Medical University School of Medicine  Nagakute Japan"},{"name":"Japanese Data Center for Hematopoietic Cell Transplantation  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-8463","authenticated-orcid":false,"given":"Takaaki","family":"Konuma","sequence":"additional","affiliation":[{"name":"The Institute of Medical Science The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-9775","authenticated-orcid":false,"given":"Masamitsu","family":"Yanada","sequence":"additional","affiliation":[{"name":"Nagoya City University East Medical Center  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-06094-z"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"68","article-title":"Hematopoietic Cell Transplantation for Older Acute Myeloid Leukemia Patients in First Complete Remission: Results of a Randomized Phase III Study","volume":"110","author":"Niederwieser D.","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-514778"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.11.017"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1535115"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02295-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.1190.1190"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06239"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1894-x"},{"issue":"3","key":"e_1_2_12_12_1","first-page":"250","article-title":"Chronic Graft\u2010Versus\u2010Host Disease and Other Late Complications of Bone Marrow Transplantation","volume":"28","author":"Sullivan K. 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