{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:15:35Z","timestamp":1777968935413,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201400003I"],"award-info":[{"award-number":["HHSN268201400003I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201400002I"],"award-info":[{"award-number":["HHSN268201400002I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The epidemiology of myelodysplastic syndromes\/neoplasms (MDS) is challenging to define due to inconsistent reporting, complex diagnostic procedures, and evolving diagnostic criteria. Using the National MDS Natural History Study\u2014a prospective cohort with centrally adjudicated histopathology and genetic variant review\u2014we characterized the landscape of MDS across the United States and identified differences across demographics. Among 2115 participants, 64% (1346) had an MDS spectrum condition, including MDS (24%), MDS\/myeloproliferative neoplasm (5%) and precursor conditions\u2014clonal cytopenia of undetermined significance (22%) and idiopathic cytopenia\/dysplasia of undetermined significance (13%). The median age was 74\u2009years, and participants were predominantly male (66%), White (91%), and Non\u2010Hispanic (92%). Myeloid\u2010associated variants were detected in 68% of participants, most commonly in\n                    <jats:italic>TET2, DNMT3A, ASXL1, SF3B1,<\/jats:italic>\n                    and\n                    <jats:italic>SRSF2<\/jats:italic>\n                    . Black, compared to White, participants were younger at diagnosis (69 vs. 74\u2009years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), had equal or increased prevalence of higher\u2010risk MDS, lower hemoglobin, and higher peripheral blood blasts, yet were less likely to receive MDS\u2010directed therapy (14% vs. 42%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008). Black and Hispanic participants had fewer detectable gene mutations than White participants. Females had lower variant allele frequencies and fewer RNA splicing gene mutations than males. After multivariable adjustment,\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations, MDS diagnosis, and higher\u2010risk disease were associated with worse progression\u2010free and overall survival; age was also associated with overall survival. Black race trended toward improved progression\u2010free survival. These findings highlight the need for enhanced understanding of MDS pathogenesis across patient groups and refined prognostic tools to improve personalized management of MDS spectrum conditions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT02775383\n                  <\/jats:p>","DOI":"10.1002\/ajh.70279","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:59:42Z","timestamp":1774843182000},"page":"1407-1420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, Genetic, and Pathologic Variability in Myelodysplastic Syndromes and Precursor Conditions Across Race, Ethnicity, and Sex"],"prefix":"10.1002","volume":"101","author":[{"given":"Nancy","family":"Gillis","sequence":"first","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center and Research Institute  Tampa Florida USA"},{"name":"Department of Malignant Hematology Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Colin\u2010Leitzinger","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Han","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Otterstatter","sequence":"additional","affiliation":[{"name":"The Emmes Company  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Sherman","sequence":"additional","affiliation":[{"name":"The Emmes Company  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn C.","family":"Moscinski","sequence":"additional","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ellen","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Painter","sequence":"additional","affiliation":[{"name":"Tissue Core Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Abel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tareq","family":"Al Baghdadi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Trinity Health IHA Medical Group Michigan Cancer Research Consortium  Ypsilanti Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Joachim","family":"Deeg","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center, Seattle, Washington University of Washington  Seattle Washington USA"},{"name":"University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-1708","authenticated-orcid":false,"given":"James M.","family":"Foran","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology Mayo Clinic Comprehensive Cancer Center  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Gore","sequence":"additional","affiliation":[{"name":"Investigational Drug Branch, Cancer Therapy Evaluation Program National Cancer Institute  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra M.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven H.","family":"Kroft","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane Jijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Illinois CancerCare Heartland NCORP  Peoria Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Saber","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, CIBMTR Milwaukee Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamsuddin","family":"Virani","sequence":"additional","affiliation":[{"name":"Vince Lombardi Cancer Clinic Aurora Health Care  Burlington Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Bejar","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology UC San Diego Moores Cancer Center  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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