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Here, we report 5\u2010year follow\u2010up results, including assessments of durable response, survival, and safety. We also investigated risk factors and biomarkers associated with treatment resistance or relapse and evaluated salvage therapies after CAR\u2010T cell failure. Among 87 patients with r\/r NHL treated with TanCAR7, the objective response rate was 78% (complete remission rate, 70%) with a median follow\u2010up of 63.4\u2009months. At data cut\u2010off, 40% of patients remained in remission. Median overall survival (OS) was not reached, with an estimated 5\u2010year OS rate of 60.1% and median progression\u2010free survival (PFS) of 33\u2009months. No new or unexpected TanCAR7\u2010related serious adverse events or deaths were observed. High tumor burden and systemic inflammation were risk factors for resistance and relapse. In addition to CAR\u2010T cell expansion in peripheral blood, high levels of endogenous CD8\u2009+\u2009T cells and total lymphocytes after infusion correlated with treatment benefit. Salvage chemotherapy post TanCAR7 failure showed limited efficacy, whereas targeted therapy or secondary CAR\u2010T cell therapy achieved clinical responses in a subset of patients. This first\u2010ever 5\u2010year follow\u2010up analysis of a dual\u2010targeted CAR T\u2010cell therapy shows long\u2010term remission potential and no new safety signals in patients with r\/r NHL.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    : NCT03097770\n                  <\/jats:p>","DOI":"10.1002\/ajh.70281","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:39:36Z","timestamp":1773121176000},"page":"1226-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Five\u2010Year Follow\u2010Up: Tandem\n                    <scp>CD19<\/scp>\n                    \/\n                    <scp>CD20 CAR<\/scp>\n                    T Therapy Enduring Impact on Refractory\/Relapsed Non\u2010Hodgkin Lymphoma"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-1847","authenticated-orcid":false,"given":"Fuxin","family":"Han","sequence":"first","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Department of Hematology, the Second Medical Center &amp; National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-9889","authenticated-orcid":false,"given":"Zhiqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-3899","authenticated-orcid":false,"given":"Weidong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-422X","authenticated-orcid":false,"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Therapeutic, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00591-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021243"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280678"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01379-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2301665"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.10.020"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02370"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30864-7"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31366-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708566"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000905"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407222"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61403-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01038-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020621"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02220-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01969-y"},{"key":"e_1_2_10_20_1","first-page":"349","article-title":"GLA\/DRST Real\u2010World Outcome Analysis of CAR T\u2010Cell Therapies for Large B\u2010Cell Lymphoma in Germany","volume":"140","author":"Bethge W. 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