{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:15:58Z","timestamp":1777968958561,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Data to guide management of isolated bland cancer\u2010associated splanchnic vein thrombosis (CA\u2010SpVT) are limited. We aimed to assess the role of anticoagulation (AC) and bleeding and thrombosis in patients with CA\u2010SpVT. We conducted a dual\u2010center retrospective cohort study of adults with incident, isolated, bland CA\u2010SpVT from 2011 to 2020. The primary outcome was major bleeding (MB); other outcomes included usual\u2010site venous thromboembolism (VTE) recurrence and progression\/recanalization of CA\u2010SpVT. Time\u2010to\u2010event outcomes were analyzed with weighted Cox models adjusting for cancer type, stage, SpVT location, and whether symptomatic. For SpVT recanalization\/progression, differences were estimated using weighted average treatment effects (ATEs). After excluding tumor thrombus, we included 437 patients with notable characteristics of median age 60\u2009years, portal vein thrombosis (81.2%), and underlying hepatocellular cancer (35.9%). Of these, 29.5% received therapeutic AC. At 6\u2009months, there were 11.9% MB and 6.4% incident usual\u2010site VTE events. Among 308 patients with follow\u2010up imaging, the 1\u2010year thrombus progression rate was 19.8% and thrombus recanalization was 28.6%. In the adjusted analysis, there were numerically higher rates of MB with AC (adjusted hazard ratio [aHR] 1.93, 95% confidence interval [CI] 0.97\u20133.87) and no significant difference in the incidence of VTE (aHR 1.41, 95% CI 0.56\u20133.51). AC was associated with significantly higher likelihood of venous recanalization (ATE +24% 95% CI 13%\u201335%) and significantly lower likelihood of thrombus progression (ATE \u201314% 95% CI \u201323% to \u22125%). In patients with isolated bland CA\u2010SpVT, AC was associated with thrombus recanalization and limited thrombus progression; effects were offset by a potentially higher risk of MB.<\/jats:p>","DOI":"10.1002\/ajh.70287","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:26:08Z","timestamp":1774607168000},"page":"1379-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Anticoagulation in Patients With Isolated Cancer\u2010Associated Splanchnic Vein Thrombosis: A Dual\u2010Center Cohort Study"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-4262","authenticated-orcid":false,"given":"Abhilasha","family":"Borad","sequence":"first","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Michael","family":"Andersen","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology University of Washington, Fred Hutchinson Cancer Center  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Guffey","sequence":"additional","affiliation":[{"name":"Institute for Clinical &amp; Translational Research, Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanqing","family":"Shang","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Keck School of Medicine of University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Y.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Keck School of Medicine of University of Southern California  Los Angeles California USA"},{"name":"Los Angeles General Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Fernandez Turizo","sequence":"additional","affiliation":[{"name":"Hematology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Berry","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies, Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey I.","family":"Zwicker","sequence":"additional","affiliation":[{"name":"Hematology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Weill Cornell Medical College  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushad","family":"Patell","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies, Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-2309","authenticated-orcid":false,"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201004\u2010460121"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016\u20100214"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007338"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005819"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S197732"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101722607"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(16)30020\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032262"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17863"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2023.10.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014249"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.02.024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0027"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2019.06.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1781"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26120"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14836"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003442"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01461"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.01.019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12733"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2023.100154"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2005.01204.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2016.1260466"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2022-011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7084"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","unstructured":"\u201cThe Use of Propensity Score Methods With Survival or Time\u2010To\u2010Event Outcomes: Reporting Measures of Effect Similar to Those Used in Randomized Experiments\u2014Austin\u20142014\u2014Statistics in Medicine\u2014Wiley Online Library \u201daccessed February 23 2025 https:\/\/doi.org\/10.1002\/sim.5984.","DOI":"10.1002\/sim.5984"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006827"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100033\u20101363473"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.131271"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2006.02082.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201001\u20100108"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100115"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000336\u2010y"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.8034"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915103"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1711948"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025362"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201003\u2010631119"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000240\u20103"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102016.1.188"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15138"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.10.002"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2023.09.004"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.06.029"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620716680333"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:24:39Z","timestamp":1777965879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ajh.70287"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70287","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}