{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:22:33Z","timestamp":1789593753677,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300164"],"award-info":[{"award-number":["82300164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270179"],"award-info":[{"award-number":["82270179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221287"],"award-info":[{"award-number":["BK20221287"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230296"],"award-info":[{"award-number":["BK20230296"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myelodysplastic syndromes\/neoplasms (MDS) represent a heterogeneous group of clonal hematopoietic stem cell diseases with high risks of acute myeloid leukemia (AML) transformation. To emphasize the characteristics of AML transformation, the International Consensus Classification (ICC) has classified MDS with excess blasts (10%\u201319%) as MDS\/AML. Recently, a clinical\u2010molecular prognostic model International Prognostic Scoring System Molecular (IPSS\u2010M) is developed, which improves the risk stratification of MDS. However, these molecular risk factors were analyzed in a cohort of highly heterogeneous patients with MDS including MDS\/AML. Herein, we re\u2010evaluated and compared the molecular risk factors in MDS (blasts &lt;\u200910%) and MDS\/AML (blasts 10%\u201319%) defined by ICC. Notably, there is a significant difference in molecular landscape between MDS and MDS\/AML. Importantly, most of the risk factors presented in MDS was not shown in MDS\/AML except for TP53 aberrations and FLT3\u2010ITD mutation. Since the IPSS\u2010R and IPSS\u2010M showed a poorly prognostic separation for MDS\/AML patients, we further established a new prognostic model MDS\/AML\u2010IPSS\u2010M and significantly improved its prognostic discrimination ability. Taking together, our research findings enhance the understanding of the molecular biology of MDS and can provide important guidance for the clinical identification of MDS\/AML patients that might benefit clinical decision\u2010making and therapeutic research.<\/jats:p>","DOI":"10.1002\/ajh.70296","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:47:02Z","timestamp":1774928822000},"page":"1421-1425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinctive Molecular Risk Factors Between\n                    <scp>MDS<\/scp>\n                    and\n                    <scp>MDS<\/scp>\n                    \/\n                    <scp>AML<\/scp>\n                    Defined by\n                    <scp>ICC<\/scp>"],"prefix":"10.1002","volume":"101","author":[{"given":"Ting\u2010juan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Jiangsu University, Zhenjiang Clinical Research Center of Hematology  Zhenjiang Jiangsu China"},{"name":"Institute of Hematology Jiangsu University  Zhenjiang Jiangsu China"},{"name":"The Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang\u2010jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Jiangsu University, Zhenjiang Clinical Research Center of Hematology  Zhenjiang Jiangsu China"},{"name":"Institute of Hematology Jiangsu University  Zhenjiang Jiangsu China"},{"name":"The Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Jiangsu University, Zhenjiang Clinical Research Center of Hematology  Zhenjiang Jiangsu China"},{"name":"Institute of Hematology Jiangsu University  Zhenjiang Jiangsu China"},{"name":"The Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7187-179X","authenticated-orcid":false,"given":"Jing\u2010dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Jiangsu University, Zhenjiang Clinical Research Center of Hematology  Zhenjiang Jiangsu China"},{"name":"Institute of Hematology Jiangsu University  Zhenjiang Jiangsu China"},{"name":"The Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00402-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011304"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26799"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00328-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01784"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01910-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01831-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00894-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02004-w"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"D.Kwag B.Bae J.Jung et\u00a0al. \u201cClinical Outcomes of WHO 2022 and ICC MDS Entities With Risk Stratification by IPSS\u2010R and IPSS\u2010M \u201d Haematologica ahead of print October 30 2025 https:\/\/doi.org\/10.3324\/haematol.2025.288090.","DOI":"10.3324\/haematol.2025.288090"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02814-0"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27070"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02180-3"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70296","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:24:16Z","timestamp":1777965856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ajh.70296"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70296","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}