{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:41:37Z","timestamp":1790221297969,"version":"4.1.0"},"reference-count":112,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Morbidity and mortality in bone marrow failure syndromes such as acquired aplastic anemia (AA) are driven by severe and prolonged cytopenia. Allogeneic hematopoietic stem cell transplantation (alloHSCT) is potentially curative and offers a rapid route to hematopoietic reconstitution. In 2026, reduced\u2010toxicity conditioning, improved supportive care, and novel graft versus host disease prevention through post\u2010transplant cyclophosphamide (PTCy)\u2010based platforms have brought alternative donor transplantation into the mainstream. This review examines contemporary evidence, particularly looking at the expanded role of transplant outside the widely accepted setting of younger patients with matched sibling donors and offers a pragmatic framework for context\u2010adapted decision\u2010making.<\/jats:p>","DOI":"10.1002\/ajh.70319","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:25:19Z","timestamp":1776129919000},"page":"1561-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Allogeneic\n                    <scp>HSCT<\/scp>\n                    in Aplastic Anemia: Current Evidence, Controversies, and Practical Decision\u2010Making"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9251-3609","authenticated-orcid":false,"given":"Arjun Datt","family":"Law","sequence":"first","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-7168","authenticated-orcid":false,"given":"Jeffrey H.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_16_2_1","article-title":"Allogeneic Hematopoietic Cell Transplantation for Aplastic Anemia: A Single Institution Experience Across Six Decades","author":"Olivieri D. J.","journal-title":"Blood Advances"},{"issue":"25","key":"e_1_2_16_3_1","first-page":"3031","article-title":"Alternative Donor BMT With Posttransplant Cyclophosphamide as Initial Therapy for Acquired Severe Aplastic Anemia","volume":"141","author":"DeZern A. E.","year":"2023","journal-title":"Blood"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/hemoncstem.HEMONCSTEM-D-24-00037"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.09.017"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01332-8"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004345"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.05.022"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-743112"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16153"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2021.101280"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V48.1.63.63"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2012.47.2.126"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2215943"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00069-6"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109965"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.2.606.606"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2001.v7.pm11215697"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1612789"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00710"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012130"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0457-1"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108680"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302103080602"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-807859"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000722"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.026682"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024173"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.138727"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2004"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-876284"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1004787"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955095"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-020-0340-x"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.05.027"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.06.031"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.0952"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014858"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-663823"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003922"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2026.01.057"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.012"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.115345"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.10.006"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-01-829630"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001729"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003342"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00206-X"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.04.015"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.09.009"},{"issue":"10","key":"e_1_2_16_51_1","first-page":"310","article-title":"Long\u2010Term Follow\u2010Up of the Baltimore Experience With Hematopoietic Cell Transplantation for Severe Aplastic Anemia Using Post\u2010Transplantation Cyclophosphamide","volume":"32","author":"DeZern A. E.","year":"2025","journal-title":"Transplantation and Cellular Therapy"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014781"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2503189"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00184"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14225"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.12.628"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-025-02633-y"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0897-2"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.837335"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280758"},{"issue":"1","key":"e_1_2_16_62_1","first-page":"781","article-title":"Similar Outcomes Between HLA\u2010Haploid and Matched Sibling Donor Hematopoietic Stem Cell Transplantation: A Multicenter, Retrospective Study and Severe Aplastic Anemia Transplant\u2010Specific Prognostic Scoring System","volume":"104","author":"Gao M.","year":"2025","journal-title":"Annals of Hematology"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217594"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.06.012"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.08.005"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01092-x"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02474-1"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01364-0"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008792"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.70380"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-01238"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.091074"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.054841"},{"issue":"11","key":"e_1_2_16_74_1","article-title":"Bone Marrow Versus Peripheral Blood Allogeneic Haematopoietic Stem Cell Transplantation for Haematological Malignancies in Adults","volume":"11","author":"Kiene S.","year":"2024","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203517"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.01.012"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.212"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148510"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.04.010"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.01.034"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011719"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19236"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-005041"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2001.v7.pm11349807"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04664-z"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24252"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.09.025"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705165"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.115"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-045625"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.01.029"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12263"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1818065"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.05.015"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.284022"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02251-0"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13828"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.896034"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-025-02577-3"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.10.004"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01362-2"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.09.027"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.07.012"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.153"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-025-06440-9"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334953"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.050096"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04271-4"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.12.001"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310143291603"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.04.017"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.203919"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-025-02540-2"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70319","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:47:43Z","timestamp":1780386463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":112,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ajh.70319"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70319","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}