{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:12:44Z","timestamp":1790712764300,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mycosis fungoides (MF) is a rare extranodal T\u2010cell lymphoma with primary cutaneous involvement. While it is the most common primary skin lymphoma, large\u2010scale real\u2010world data defining survival benchmarks and the prognostic significance of specific nodal sites remain limited. To address this, we conducted a retrospective cohort study using the TriNetX global health research network and identified 25\u2009467 patients with MF. The 5\u2010 and 10\u2010year OS for the overall cohort was 83.4% and 74.7%, respectively. Patients with disease limited to the skin had 5\u2010 and 10\u2010year OS rates of 86.1% and 78.0%, respectively. Nodal involvement at diagnosis was associated with significantly inferior survival [adjusted HR (aHR)\u2009=\u20091.60; 95% CI: 1.50\u20131.71;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001], exhibiting 5\u2010 and 10\u2010year OS rates of 74.5% and 63.6%, respectively. Among patients with single\u2010site lymphadenopathy, survival outcomes varied substantially by anatomical site, revealing a potential prognostic hierarchy: patients with inguinal\/lower limb involvement exhibited the most favorable outcomes (5\u2010year OS 80.2%), while those with visceral lymphadenopathy had the poorest prognosis (5\u2010year OS 62.9%). In multivariable analysis, elevated LDH (aHR 3.06), lymphocytosis (aHR 1.37), and eosinophilia (aHR 1.29) were strong independent predictors of mortality, among others. To summarize, this study of over 25\u2009000 MF patients represents the largest real\u2010world analysis to date. Data suggest a potential prognostic divergence based on the anatomical site of nodal involvement. Additionally, our findings reinforce the prognostic value of LDH, eosinophils, lymphocytes and the hypopigmented and poikilodermatous variants as independent predictors of mortality, supporting their integration into routine risk stratification.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70334","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:29:48Z","timestamp":1776338988000},"page":"1618-1627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010World Outcomes of Mycosis Fungoides and Site\u2010Specific Nodal Involvement: A Registry\u2010Based Study of 25\u2009467 Patients"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8971-269X","authenticated-orcid":false,"given":"Charalampos","family":"Filippatos","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of 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