{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:19:10Z","timestamp":1788538750927,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glofitamab, a CD20\u2009\u00d7\u2009CD3 bispecific antibody, has demonstrated significant efficacy in relapsed or refractory (R\/R) B\u2010cell lymphomas. However, real\u2010world evidence on its clinical performance and immunologic correlates, particularly in the context of chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy, remains limited. This observational study included 64 patients with R\/R aggressive B\u2010cell lymphoma who received glofitamab\u2010based therapy between February 2024 and December 2025 at the First Affiliated Hospital of Soochow University. The primary endpoint was complete response (CR) rate, whereas secondary endpoints included overall response rate (ORR), progression\u2010free survival (PFS), overall survival (OS), and safety. We also analyzed the impact of prior bispecific antibody (BsAb) exposure on CAR\u2010T cell manufacturing and efficacy and assessed the relationship between peripheral T\u2010cell subsets and treatment outcomes. Among 56 evaluable patients, the CR and ORR were 41.1% and 78.7%, respectively. Median PFS and OS were not reached, with estimated 1\u2010year PFS and OS rates of 61.3% and 67.7%. Patients with non\u2010germinal center B\u2010cell (non\u2010GCB) subtype had significantly higher PFS than those with GCB subtype (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029), whereas prior CAR\u2010T therapy was associated with poorer PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022). Prior BsAb exposure did not affect CAR\u2010T manufacture or efficacy. Immunophenotyping revealed that patients achieving CR had higher baseline CD4\n                    <jats:sup>+<\/jats:sup>\n                    effector T\u2010cell counts (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04) and higher early CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell expansion (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Overall, glofitamab demonstrated durable efficacy and a manageable safety profile in R\/R aggressive B\u2010cell lymphoma, with treatment outcomes closely associated with T\u2010cell functional status, supporting its potential as an effective bridging strategy before CAR\u2010T therapy.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70359","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:46:34Z","timestamp":1778481994000},"page":"6-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Efficacy and Safety of Glofitamab\u2010Based Salvage Therapy in Chinese Patients With Relapsed or Refractory Aggressive B\u2010Cell Lymphomas"],"prefix":"10.1002","volume":"101","author":[{"given":"Jin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology, National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hematology, National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University  Suzhou 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