{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:22:16Z","timestamp":1783117336936,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500296"],"award-info":[{"award-number":["82500296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82425002"],"award-info":[{"award-number":["82425002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370223"],"award-info":[{"award-number":["82370223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341206"],"award-info":[{"award-number":["82341206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202111004"],"award-info":[{"award-number":["SZSM202111004"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Sequential allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) is a critical approach to enhance the efficacy of chimeric antigen receptor T cell (CAR\u2010T) therapy for relapsed\/refractory acute lymphoblastic leukemia (R\/R ALL). The long\u2010term survival rates following allo\u2010HSCT after CAR\u2010T cell therapy remain controversial. We previously reported the results of 122 patients with R\/R B\u2010ALL who achieved minimal residual disease negative (MRD\u2212) complete remission (CR) after anti\u2010CD19 CAR\u2010T, including 67 patients without subsequent transplantation (non\u2010transplant group) and 55 patients with subsequent haplo\u2010HSCT (transplant group). Here, we present the extended follow\u2010up of this cohort, with a median of 72.9\u2009months. Compared with the non\u2010transplant group, transplantation recipients had a higher 5\u2010year LFS (50.5% vs. 25.7%;\n p<\/jats:italic>\n \u2009<\u20090.001) and OS (53.5% vs. 25.6%;\n p<\/jats:italic>\n \u2009<\u20090.001). Multivariable analysis identified MRD positivity at transplantation as an independent factor associated with worse LFS, OS, and a higher cumulative incidence rate of relapse (CIR). MRD\u2010negative patients before transplant (MRD\u2212 group) had a lower 5\u2010year CIR compared to MRD\u2010positive patients (MRD+ group) (20.8% vs. 50.0%;\n p<\/jats:italic>\n \u2009=\u20090.014). The 5\u2010year LFS rates in the MRD+ and MRD\u2212 groups were 26.7% and 59.4%, respectively (\n p<\/jats:italic>\n \u2009=\u20090.003). The 5\u2010year OS of the MRD\u2212 group was higher than that of the MRD+ group (62.0% vs. 30.5%;\n p<\/jats:italic>\n \u2009=\u20090.006). For patients who achieve CR after CAR\u2010T therapy, haplo\u2010HSCT with pre\u2010transplant MRD negativity was associated with better long\u2010term survival. However, infections emerged as a significant complication that may reduce the long\u2010term survival benefits.\n <\/jats:p>\n \n Trial Registration:<\/jats:bold>\n ClinicalTrials.gov identifier: ChiCTR1900023957.\n <\/jats:p>","DOI":"10.1002\/ajh.70361","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:23:01Z","timestamp":1778736181000},"page":"1866-1877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010Transplant\n MRD<\/scp>\n Negativity and Age Under 40 Predict Superior Long\u2010Term Survival in Relapsed\/Refractory B\u2010\n ALL<\/scp>\n After\n CAR<\/scp>\n \u2010T Therapy Bridging to Haploidentical\n HSCT<\/scp>\n : A Multicenter Retrospective Study With 6\u2010Year Follow\u2010Up"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9522-4938","authenticated-orcid":false,"given":"Houli","family":"Zhao","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouning","family":"Lin","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-219X","authenticated-orcid":false,"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-8862","authenticated-orcid":false,"given":"Qu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-1987","authenticated-orcid":false,"given":"Aibin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanghai Tongji Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Guangdong Second Provincial General 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Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Tan Su","family":"Yin","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Tan","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology Guangdong Second Provincial General Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Changhai Hospital of Shanghai Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Institut Paoli\u2010Calmettes Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Innovative Cellular Therapeutics co, Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Shanghai YaKe Biotechnology Ltd Shanghai 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Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-1852","authenticated-orcid":false,"given":"Yongxian","family":"Hu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Hangzhou China"},{"name":"Institute of Hematology Zhejiang University Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022922"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-018192"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709919"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25108"},{"issue":"10","key":"e_1_2_12_6_1","first-page":"793","article-title":"Long\u2010Term Follow\u2010Up of Humanized and Murine CD19 CAR\u2010T\u2010Cell Therapy for B\u2010Cell Acute Lymphoblastic Leukemia","volume":"44","author":"Du M.","year":"2023","journal-title":"Zhonghua Xue Ye Xue Za 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