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To help more individuals achieve active, unrestricted lives, health care professionals must move beyond traditional prophylaxis targets by applying evolving evidence on factor VIII (FVIII) levels, optimizing prophylaxis to provide sustained bleed protection, and individualizing therapy to meet patients' needs, preferences, and real\u2010world considerations. This 3\u2010segment podcast features expert discussions on optimizing joint health across the lifespan, including subclinical bleeding and imaging\u2010based monitoring; applying current and emerging guidance on FVIII targets and factor\u2010based strategies; and integrating rebalancing agents into practice, with a focus on clinical outcomes, safety and risk mitigation, treatment burden, patient selection, and individualized hemophilia management. 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