{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:21:18Z","timestamp":1783117278965,"version":"3.54.6"},"reference-count":84,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Disease Overview<\/jats:title>\n                    <jats:p>Plasmablastic lymphoma (PBL) is a rare CD20\u2010negative aggressive lymphoma with poor prognosis when treated with standard treatment options. Although PBL is associated with HIV infection and other immunosuppressed states, it can also affect immunocompetent individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis<\/jats:title>\n                    <jats:p>\n                      The diagnosis of PBL requires a high clinical suspicion and pathological confirmation. EBV\u2010encoded RNA (EBER) expression and\n                      <jats:italic>MYC<\/jats:italic>\n                      gene rearrangements are frequently detected in the malignant cells. The differential diagnosis includes EBV+ diffuse large B\u2010cell lymphoma (DLBCL), extracavitary primary effusion lymphoma, ALK+ DLBCL, and HHV8+ large B\u2010cell lymphoma, among others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Risk Stratification<\/jats:title>\n                    <jats:p>Age\u2009\u2265\u200960\u2009years, advanced clinical stage, and high International Prognostic Index scores are associated with worse survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management<\/jats:title>\n                    <jats:p>Combination chemotherapy regimens, such as infusional EPOCH, are recommended. The addition of bortezomib or daratumumab might improve outcomes. B\u2010cell maturation antigen\u2010targeted therapies have shown early efficacy. The participation of patients with PBL in prospective clinical trials is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajh.70373","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:17:29Z","timestamp":1778847449000},"page":"1997-2006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasmablastic Lymphoma: 2026 Update on Diagnosis, Risk Stratification, and Management"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-7532","authenticated-orcid":false,"given":"Jorge J.","family":"Castillo","sequence":"first","affiliation":[{"name":"Division of Hematologic Malignancies Dana\u2010Farber Cancer Institute, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4469-3817","authenticated-orcid":false,"given":"Brady E.","family":"Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Nacional Edgardo Rebagliati Martins, and School of Health Sciences, Universidad San Ignacio de Loyola  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-7889","authenticated-orcid":false,"given":"Jorge A.","family":"Florindez","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-6238","authenticated-orcid":false,"given":"Julio C.","family":"Chavez","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Mayo Clinic Comprehensive Cancer Center  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-1846","authenticated-orcid":false,"given":"Luis","family":"Malpica","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1413"},{"key":"e_1_2_14_3_1","first-page":"321","volume-title":"WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues","author":"Stein 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