{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:38:11Z","timestamp":1787931491023,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Talquetamab is a GPRC5D\u2009\u00d7\u2009CD3 bispecific antibody approved for relapsed\/refractory multiple myeloma (RRMM). This is the first real\u2010world study to comprehensively report muco\u2010cutaneous toxicities, infections, and efficacy of talquetamab in 151 patients across five countries with the longest follow\u2010up reported enabling better efficacy and toxicity estimates. The median age was 64\u2009years; high\u2010risk cytogenetics were present in 42%; ECOG\u2009\u2265\u20092 in 22%; 12% had creatinine clearance &lt;\u200930; and 55% would not have met MonumenTAL\u20101 eligibility. Patients received a median of 6 prior lines of therapy, 53% were penta\u2010refractory, and 75% received prior BCMA therapy. Talquetamab was associated with skin toxicity in 39.7%, nail toxicity in 75.5%, dysgeusia in 60.4%, and oral toxicities in 62.9%, with grade \u2265\u20093 events uncommon (\u2264\u20094%) and dose interruptions infrequent (9.6% for skin toxicity, 6.9% for dysgeusia, and 4.0% for oral toxicities). These findings underscore the need for improved supportive care for muco\u2010cutaneous toxicities. In multivariate analysis, only platelet count &lt;\u200950 (HR 1.8, 95% CI 1.15\u20132.83) was associated with inferior PFS, while penta\u2010refractory status, absolute lymphocyte count &lt;\u20090.4, and prior BCMA\u2010targeted therapy were not statistically significant. With a median follow\u2010up of 12.7\u2009months, the overall response rate was 67.6%, median progression\u2010free survival was 7\u2009months, and 12\u2010month overall survival was 65%. This study shows that talquetamab efficacy is maintained in a heavily pretreated real\u2010world population with high prior BCMA exposure and notable comorbidity burden.<\/jats:p>","DOI":"10.1002\/ajh.70376","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:00:22Z","timestamp":1779253222000},"page":"1928-1937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Evaluation of Talquetamab for the Treatment of Relapsed\/Refractory Multiple Myeloma (\n                    <scp>RRMM<\/scp>\n                    ): An International Myeloma Working Group Immunotherapy Registry Real\u2010World Analysis"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-8007","authenticated-orcid":false,"given":"Murali","family":"Janakiram","sequence":"first","affiliation":[{"name":"City of Hope National Medical Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-2594","authenticated-orcid":false,"given":"Carlyn R.","family":"Tan","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Mian","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-4618","authenticated-orcid":false,"given":"Rakesh","family":"Popat","sequence":"additional","affiliation":[{"name":"University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Mart\u00ednez\u2010Lopez","sequence":"additional","affiliation":[{"name":"University of Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-5832","authenticated-orcid":false,"given":"Efsthathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee\u2010Joo","family":"Chng","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrugakshi","family":"Dave","sequence":"additional","affiliation":[{"name":"International Myeloma Foundation  Studio City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bal","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Garderet","sequence":"additional","affiliation":[{"name":"Service H\u00e9matologie, H\u00f4pital Universitaire Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre De Menezes Silva","family":"Corraes","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Riedhammer","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg Department of Internal Medicine II  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Steinbrunn","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg Department of Internal Medicine II  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-0171","authenticated-orcid":false,"given":"Magdalene","family":"Corona","sequence":"additional","affiliation":[{"name":"University of Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandramouli","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Singapore General Hospital and National Cancer Centre Department of Hematology  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg Department of Internal Medicine II  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Martin","sequence":"additional","affiliation":[{"name":"University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Krishnan","sequence":"additional","affiliation":[{"name":"City of Hope National Medical Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1840","article-title":"Talquetamab, a GPRC5D\u00d7CD3 Bispecific Antibody, in Patients With Relapsed or Refractory Multiple Myeloma (MonumenTAL\u20101)","volume":"389","author":"Chari A.","year":"2023","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"e_1_2_12_3_1","first-page":"1432","article-title":"CRS and ICANS With Next\u2010Generation T\u2010Cell\u2013Redirecting Therapies","volume":"141","author":"Lee M.","year":"2023","journal-title":"Blood"},{"issue":"16","key":"e_1_2_12_4_1","first-page":"4501","article-title":"Infection Risk and Management With GPRC5D\u2010 and BCMA\u2010Targeted Bispecifics","volume":"8","author":"Al Hadidi S.","year":"2024","journal-title":"Blood Advances"},{"issue":"5","key":"e_1_2_12_5_1","first-page":"445","article-title":"GPRC5D Expression in Normal Tissues and Implications for GPRC5D\u2010Targeted Therapy","volume":"140","author":"Smith E. L.","year":"2022","journal-title":"Blood"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.05.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2025.2555170"},{"key":"e_1_2_12_8_1","first-page":"2344","article-title":"Eligibility of Real\u2010World RRMM Patients for Clinical Trials","volume":"38","author":"Usmani S. Z.","year":"2020","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"e_1_2_12_9_1","first-page":"255","article-title":"Preventing Infections in Patients Receiving Bispecific Antibodies and CAR\u2010T Cells","volume":"142","author":"Hill J. A.","year":"2023","journal-title":"Blood"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091514"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009435"},{"key":"e_1_2_12_12_1","volume-title":"Supportive Care and Dose Modification Strategies for Talquetamab","author":"Chari A.","year":"2025"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285125"},{"key":"e_1_2_12_14_1","first-page":"1542","article-title":"Real\u2010World Talquetamab in Relapsed\/Refractory Multiple Myeloma: Results From a German Multicenter Cohort","volume":"38","author":"Frenking M.","year":"2024","journal-title":"Leukemia"},{"issue":"20","key":"e_1_2_12_15_1","first-page":"5000","article-title":"Real\u2010World Outcomes of Talquetamab in Patients With RRMM Treated in the United States","volume":"8","author":"Hadidi S.","year":"2024","journal-title":"Blood Advances"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.70376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.70376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:44:49Z","timestamp":1783115089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.70376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ajh.70376"],"URL":"https:\/\/doi.org\/10.1002\/ajh.70376","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2026-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}