{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:57:29Z","timestamp":1785585449563,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quizartinib is a tyrosine kinase inhibitor with single agent activity in patients with relapsed or refractory (R\/R) acute myeloid leukemia (AML) and has demonstrated efficacy in first\u2010line therapy when combined with intensive chemotherapy in both\n                    <jats:italic>FLT3<\/jats:italic>\n                    ITD\u2010negative and positive AML. The FLAG\u2010QUIDA trial was a multicenter phase 1\/2 study of quizartinib combined with FLAG\u2010IDA in adult patients with first R\/R AML. The primary objectives were to determine the recommended phase 2 dose (RP2D) in phase 1 and to establish the complete remission (CR) and CR with incomplete hematologic recovery (CRi) rates in phase 2. Nine patients were included in phase 1 and 52 in phase 2. Eighteen out of 61 (30%) patients were\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010ITD\u2010positive. The RP2D of quizartinib was established at 60\u2009mg\/day for 14\u2009days per 28\u2010day cycle. Overall, the CR\/CRi rate was 56% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200934), and the CR\/CRi plus morphologic leukemia free state (MLFS) rate was 66% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940), without differences across genetic subgroups. Measurable residual disease negativity was achieved in 38% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) of CR\/CRi patients. Thirty\u2010one patients (51%) were bridged to allogeneic stem cell transplantation after FLAG\u2010QUIDA, 28 in CR\/CRi and 3 in MLFS. Median relapse\u2010free survival was 17\u2009months as compared to 7.6\u2009months in a cohort of matched patients treated with FLAG\u2010IDA without quizartinib (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028), and median overall survival was 15.8\u2009months in the FLAG\u2010QUIDA cohort and 8.6\u2009months in the matched cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.09). No safety concerns were raised. FLAG\u2010IDA with quizartinib demonstrated promising efficacy in R\/R AML, supporting future investigations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    EudraCT number: 2019\u2010001976\u201012;\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT04112589\n                  <\/jats:p>","DOI":"10.1002\/ajh.70424","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:56:06Z","timestamp":1782791766000},"page":"2258-2268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quizartinib in Combination With\n                    <scp>FLAG<\/scp>\n                    \u2010\n                    <scp>IDA<\/scp>\n                    for Relapsed or Refractory Acute Myeloid Leukemia (\n                    <scp>FLAG<\/scp>\n                    \u2010\n                    <scp>QUIDA<\/scp>\n                    ): A\n                    <scp>PETHEMA<\/scp>\n                    Phase I\u2010\n                    <scp>II<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-513X","authenticated-orcid":false,"given":"Teresa","family":"Bernal","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario Central de Asturias  Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias  Oviedo Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Zambrano M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario San Agust\u00edn de Avil\u00e9s  Avil\u00e9s Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Rodr\u00edguez\u2010Veiga","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital U. La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-6733","authenticated-orcid":false,"given":"Eduardo","family":"Rodr\u00edguez\u2010Arbol\u00ed","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS\/CSIC), Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-1208","authenticated-orcid":false,"given":"Juan Manuel","family":"Bergua\u2010Burgu\u00e9s","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital San Pedro de Alc\u00e1ntara  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vives","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, ICO Badalona\u2010Hospital Universitari Germans Trias i Pujol, Institut de Recerca Josep Carreras  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Arn\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Institut Catal\u00e1 D'oncologia Hospitalet del Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mart\u00ednez S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital U. 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Herrera\u2010Puente","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Serrano\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Reina Sof\u00eda, C\u00f3rdoba, IMIBIC, UCO  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Rubio","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Jerez de la Frontera  Jerez de la Frontera Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Marchante\u2010Cepillo","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Jerez de la Frontera  Jerez de la Frontera Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cervera\u2010Calvo","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Juan XXIII  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Novo Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Son Espasses  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Fern\u00e1ndez Mart\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Insular Materno\u2010Infantil  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gil Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital General de Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rodr\u00edguez\u2010Medina","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Negr\u00edn  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Noriega\u2010Concepci\u00f3n","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Complejo Universitario  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Alfonso\u2010Pi\u00e9rola","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Cl\u00ednica Universitaria de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Loredo","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-032X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Antu\u00f1a\u2010Casal","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Docencia Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Boluda","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital U. 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