{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:09:47Z","timestamp":1792253387435,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Chronic liver disease (CLD)\u2010related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD\u2010related thrombocytopenia who were undergoing elective invasive procedures. In this multicenter, randomized (2:1), double\u2010blind, placebo\u2010controlled phase III trial, 120 adult Chinese patients with CLD\u2010related thrombocytopenia (platelet count <\u200950 \u00d7\u200910\n 9<\/jats:sup>\n \/L) received rhTPO (\n n<\/jats:italic>\n =\u200980) or placebo (\n n<\/jats:italic>\n =\u200940) once daily for up to 5 or 7\u2009days. The primary endpoint was the proportion of patients with sustained platelet counts \u2265\u200950 \u00d7\u200910\n 9<\/jats:sup>\n \/L from 24 h before invasive procedure to 7\u2009days post\u2010procedure, without requiring emergency bleeding management. The primary endpoint was achieved by 85.0% of patients in the rhTPO group versus 12.5% in the placebo group (\n p<\/jats:italic>\n \u2009<\u20090.0001). Preoperatively, platelet counts \u2265\u200950 \u00d7\u200910\n 9<\/jats:sup>\n \/L were achieved in 92.5% and 20.0% of patients in the rhTPO and placebo groups, respectively (\n p<\/jats:italic>\n \u2009<\u20090.0001). Platelet transfusion was avoided in 92.5% of rhTPO\u2010treated patients versus 25.0% of placebo\u2010treated patients (\n p<\/jats:italic>\n \u2009<\u20090.0001). The median duration of platelet counts \u2265\u200950 \u00d7\u200910\n 9<\/jats:sup>\n \/L was significantly longer with rhTPO than with placebo (21.0 vs. 3.0\u2009days,\n p<\/jats:italic>\n =\u20090.0007). Treatment\u2010related treatment\u2010emergent adverse events (TEAEs) occurred in 12.5% of patients in both the rhTPO and placebo groups. No treatment\u2010related serious adverse events were reported. Overall, rhTPO was effective and well tolerated in patients with CLD\u2010related thrombocytopenia and may represent a viable therapeutic option for those undergoing elective invasive procedures.\n <\/jats:p>\n \n Trial Registration:<\/jats:bold>\n www.chinadrugtrials.org.cn<\/jats:ext-link>\n : number CTR20230919.\n <\/jats:p>","DOI":"10.1002\/ajh.70444","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:12:46Z","timestamp":1785244366000},"page":"2571-2580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5432-089X","authenticated-orcid":false,"given":"Yifan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1987-6706","authenticated-orcid":false,"given":"Ning","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-3876","authenticated-orcid":false,"given":"Jinghang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Liaocheng People's Hospital Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hepatology The First Hospital of Jilin University Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Henan Provincial People's Hospital Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3692-7655","authenticated-orcid":false,"given":"Yongning","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qingdao Municipal Hospital Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-1407","authenticated-orcid":false,"given":"Youwen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Zhenjiang Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-8583","authenticated-orcid":false,"given":"Jinlin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"An","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Sixth People's Hospital of Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-8175","authenticated-orcid":false,"given":"Wen","family":"Xie","sequence":"additional","affiliation":[{"name":"Center of Liver Diseases Beijing Ditan Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Hepatology Guangzhou Eighth People's Hospital, Guangzhou Medical University Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Infectious and Liver Diseases The Second Hospital of Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"The Department of Liver Surgery & Liver Transplantation Centre West China Hospital, Sichuan University Sichuan 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