{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:19:10Z","timestamp":1788538750666,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Outcomes in older patients with Hodgkin lymphoma (HL) are compromised by the interplay of patient frailty and disease aggressiveness; however, current stratification tools, including the International Prognostic Score (IPS) and Comprehensive Geriatric Assessment (CGA), lack sufficient prognostic discrimination in the older HL population. We developed and validated a prognostic model integrating metabolic tumor burden and geriatric assessment. In this retrospective study across 14 centers in China between 2006 and 2024, we enrolled 306 patients aged \u2265\u200960\u2009years with histologically confirmed HL. Patients were randomly partitioned into training (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009250) and validation (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200956) cohorts. Among the 306 patients, 98 deaths and 130 progression events were recorded during follow\u2010up. We analyzed 21 candidate variables. The least absolute shrinkage and selection operator (LASSO) analysis and multivariable Cox regression identified five independent predictors for 5\u2010year overall survival (OS): age\u2009&gt;\u200973\u2009years, baseline 18F\u2010FDG PET\/CT\u2010derived total lesion glycolysis (TLG)\u2009&gt;\u2009200, hemoglobin \u2264\u2009101\u2009g\/L, activities of daily living (ADL) dependence, and lymphocyte\u2010depleted classical Hodgkin lymphoma (LDCHL). A weighted Geriatric Risk Score stratified patients into low\u2010, intermediate\u2010, and high\u2010risk groups. In the validation cohort, the Geriatric Risk Score showed higher discriminatory accuracy than the CGA for both OS (C\u2010index, 0.770 [95% CI, 0.674\u20130.867] vs. 0.671 [0.581\u20130.762]) and PFS (0.761 [0.668\u20130.853] vs. 0.635 [0.535\u20130.735]). Among advanced\u2010stage (Ann Arbor stage III\u2013IV) patients, it also outperformed the IPS\u20107 and IPS\u20103. By integrating metabolic tumor burden and geriatric assessment, the Geriatric Risk Score improves risk stratification over existing tools in older patients with HL.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70456","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:30:53Z","timestamp":1786606253000},"page":"50-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Novel Geriatric Risk Score for Prognostication in Older Patients With Hodgkin Lymphoma: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-5679","authenticated-orcid":false,"given":"Peiqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute &amp; Hospital, National Clinical Research Center for Cancer, Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Fourth Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-0079","authenticated-orcid":false,"given":"Jiesong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma &amp; Head and Neck Oncology, College of Clinical Medicine for Oncology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-5160","authenticated-orcid":false,"given":"Yajun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Hematology The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Yantai Yuhuangding Hospital Affiliated to Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-2154","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-6598","authenticated-orcid":false,"given":"Shu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Harbin Medical University Cancer Hospital, Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1982-7131","authenticated-orcid":false,"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukai","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-0570","authenticated-orcid":false,"given":"Jianxia","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanxi Provincial People's Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-1743","authenticated-orcid":false,"given":"Ji","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9897-0534","authenticated-orcid":false,"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Geneseeq Technology Inc.  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Yu","sequence":"additional","affiliation":[{"name":"Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei 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