{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:38Z","timestamp":1791812738120,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["70114570"],"award-info":[{"award-number":["70114570"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008884","name":"Edward P. Evans Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG\u201026537\u20102021"],"award-info":[{"award-number":["IG\u201026537\u20102021"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Baseline IPSS\u2010M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo\u2010HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of response when adjusting for IPSS\u2010M risk and treatment strategy remains unclear. Hence, we used the VALIDATE database of the International Consortium for MDS (icMDS) to\u00a0evaluate the impact of International Working Group (IWG) 2023 best response on OS in 715 HMA\u2010treated, higher\u2010risk MDS patients stratified by baseline IPSS\u2010M risk and their treatment strategy (subsequent allo\u2010HCT vs. medical therapy alone) treating both best response and allo\u2010HCT as time\u2010dependent variables. Baseline IPSS\u2010M risk (hazard ratio (HR): 0.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and receipt of allo\u2010HCT (HR:\u00a00.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were the strongest independent predictors of OS, whereas achievement of composite complete response (cCR) had a more modest impact on OS (HR: 0.8,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Among patients treated with medical therapy alone, achieving cCR improved OS significantly (HR: 0.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). In contrast, among transplanted patients, cCR did not retain independent prognostic value for post\u2010transplant survival after adjusting for baseline IPSS\u2010M (HR: 0.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.634). Achieving cCR did not fully overcome adverse disease biology as OS continued to segregate according to baseline IPSS\u2010M risk. In summary, achieving cCR improves outcomes in non\u2010transplanted patients, but it does not significantly impact post\u2010transplant OS, suggesting that failure to achieve cCR with HMA may not warrant delay or preclude allo\u2010HCT. Clinical trials should consider response in the context of IPSS\u2010M risk distribution and treatment strategy (subsequent allo\u2010HCT vs. medical therapy alone) to avoid overinterpretation of high response rates.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70474","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:06:10Z","timestamp":1787835970000},"page":"2786-2798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Response to Hypomethylating Agent\u2010Based Therapy on Survival Outcomes in the Context of Baseline Clinical\u2010Molecular Risk and Transplant Status in Patients With Higher\u2010Risk Myelodysplastic Syndromes\/Neoplasms: An analysis From the International Consortium for MDS (icMDS)"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-861X","authenticated-orcid":false,"given":"Benjamin","family":"Rolles","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Internal Medicine Section of Medical Oncology and Hematology, Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-0902","authenticated-orcid":false,"given":"Jan Philipp","family":"Bewersdorf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Medical Oncology and Hematology, Yale University  New Haven Connecticut USA"},{"name":"Department of Medicine, Leukemia Service Memorial Sloan Kettering Cancer Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Kewan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Medical Oncology and Hematology, Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-3276","authenticated-orcid":false,"given":"Ondrej","family":"Blaha","sequence":"additional","affiliation":[{"name":"School of Public Health, Yale Center for Analytical Sciences, Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9162-0579","authenticated-orcid":false,"given":"Jessica M.","family":"Stempel","sequence":"additional","affiliation":[{"name":"School of Public Health, Yale Center for Analytical Sciences, Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-8829","authenticated-orcid":false,"given":"Luca","family":"Lanino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Medical Oncology and Hematology, Yale University  New Haven Connecticut USA"},{"name":"IRCCS Humanitas Research Hospital  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla H.","family":"Al Ali","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-4609","authenticated-orcid":false,"given":"Amy E.","family":"DeZern","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-6524","authenticated-orcid":false,"given":"Mikkael A.","family":"Sekeres","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-0996","authenticated-orcid":false,"given":"Geoffrey L.","family":"Uy","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-2279","authenticated-orcid":false,"given":"Samuel","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-3614","authenticated-orcid":false,"given":"Hetty E.","family":"Carraway","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Taussig Cancer Institute, Leukemia Program, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-7284","authenticated-orcid":false,"given":"Pinkal","family":"Desai","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0288-8248","authenticated-orcid":false,"given":"Elizabeth A.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leukemia Service Memorial Sloan Kettering Cancer Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"McMahon","sequence":"additional","affiliation":[{"name":"University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory M.","family":"Shallis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Medical Oncology and Hematology, Yale University  New Haven Connecticut USA"},{"name":"Department of Malignant Hematology H. 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