{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:56Z","timestamp":1791812756806,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thrombopoietin receptor agonists (TPO\u2010RAs), such as romiplostim, are commonly utilized to facilitate timely platelet recovery and administration of chemotherapy in patients with cancer and chemotherapy\u2010induced thrombocytopenia (CIT). However, there are limited data on the effect of TPO\u2010RAs on clinically important outcomes. A target trial emulation study was implemented to assess the effects of romiplostim in patients with solid tumors and persistent CIT, compared to controls. Patients were exact\u2010matched on chemotherapy, cancer type, degree of thrombocytopenia, and 1:1 propensity\u2010score\u2010matched on clinical\/laboratory variables on Day 1 of romiplostim treatment or quasi\u2010index date for controls. Study outcomes included overall survival over 24\u2009months and venous thromboembolism (VTE) at 6\u2009months. This study included 165 romiplostim\u2010treated patients and 165 controls. Baseline characteristics were well\u2010balanced. The median age was 61\u2009years and 52% were female. The median romiplostim duration was 1.38\u2009months. Median overall survival was 13\u2009months (95% CI: 9.9\u201323) in the romiplostim group and 9.5\u2009months (95% CI: 7.1\u201314.0) in controls (hazard ratio [HR] 0.86 [95% CI: 0.65\u20131.13]). There was a numerical improvement in survival with romiplostim (0.80 [95% CI: 0.60\u20131.06]) which was statistically significant in the subgroup of patients with metastatic disease (HR 0.70 [95% CI: 0.52\u20130.95]). The 6\u2010month cumulative incidence of VTE was 10.0% (95% CI: 6.3%\u201316.0%) in the romiplostim group and 8.0% (95% CI: 4.5%\u201313.0%) in controls (HR 1.31 [95% CI: 0.64\u20132.70]), with death as a competing risk. In conclusion, these results support the safety of romiplostim in CIT with observed numerical improvement in overall survival at 2\u2009years.<\/jats:p>","DOI":"10.1002\/ajh.70476","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:50:29Z","timestamp":1787305829000},"page":"2726-2735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinically Relevant Outcomes With Romiplostim in Patients With Solid Tumors and Persistent Chemotherapy Induced Thrombocytopenia"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-2879","authenticated-orcid":false,"given":"Cy R.","family":"Wilkins","sequence":"first","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Weill Cornell Medical College  New York New York 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Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Frenzel","sequence":"additional","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-775X","authenticated-orcid":false,"given":"Jodi V.","family":"Mones","sequence":"additional","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Parameswaran","sequence":"additional","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Shteynberg","sequence":"additional","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"New York Medical College  Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Spectre","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Beilinson Hospital, Rabin Medical Center  Petah Tikva Israel"},{"name":"The Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mantha","sequence":"additional","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-6893","authenticated-orcid":false,"given":"Jeffrey I.","family":"Zwicker","sequence":"additional","affiliation":[{"name":"Hematology Service Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Weill Cornell Medical College  New York New York 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