{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:45Z","timestamp":1791812745472,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Venetoclax (Ven) plus hypomethylating agents (HMA) is standard frontline therapy for newly diagnosed AML (ND\u2010AML) patients unfit for intensive chemotherapy and is also considered in younger, fit patients. However, consolidation with allogeneic stem cell transplant (ASCT) is often required to secure durable remission. The current study examines posttransplant outcomes in patients with ND\u2010AML treated with frontline Ven\u2010HMA who subsequently underwent ASCT. A total of 111 ND\u2010AML patients (58% male, 60% secondary\/therapy\u2010related, median age 70\u2009years [range, 37\u201380]) received a median of 3\u2009cycles of Ven\u2010HMA. Mutations at the time of diagnosis included\n                    <jats:italic>RUNX1<\/jats:italic>\n                    (18%),\n                    <jats:italic>SRSF2<\/jats:italic>\n                    (17%),\n                    <jats:italic>TP53<\/jats:italic>\n                    (16%),\n                    <jats:italic>ASXL1<\/jats:italic>\n                    ,\n                    <jats:italic>IDH2<\/jats:italic>\n                    ,\n                    <jats:italic>K\/NRAS<\/jats:italic>\n                    ,\n                    <jats:italic>TET2<\/jats:italic>\n                    (14% each),\n                    <jats:italic>STAG2<\/jats:italic>\n                    (11%),\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    (8%). All patients were in CR\/CRi at the time of transplant including 88% after Ven\u2010HMA. Measurable residual disease (MRD) by flow cytometry was detectable in 18\/76 (24%) patients. Donors were mostly HLA\u2010matched unrelated (75%); 51% receiving fludarabine\/melphalan conditioning and 67% posttransplant cyclophosphamide. At a median follow\u2010up of 15\u2009months, 42 (38%) of patients have died and 18 (16%) experienced posttransplant relapse. Median posttransplant survival was not reached (NR), with 1\u2010, 2\u2010, 3\u2010year survival rates of 69%\/60%\/57%, respectively. On multivariate analysis, age \u2265\u200965\u2009years,\n                    <jats:italic>STAG2<\/jats:italic>\n                    mutation (\n                    <jats:italic>STAG2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>MUT<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>)<\/jats:italic>\n                    , and\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>MUT<\/jats:italic>\n                    <\/jats:sup>\n                    were associated with superior posttransplant survival. Patients were stratified into low\u2010 (0\u20131 point), intermediate\u2010 (2 points), and high\u2010risk (3 points); age &lt;\u200965\u2009years,\n                    <jats:italic>STAG2<\/jats:italic>\n                    wild type, and\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    wild type, with 3\u2010year survival rates of 89%, 59%, and 19%, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Taken together, age,\n                    <jats:italic>STAG2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>MUT<\/jats:italic>\n                    <\/jats:sup>\n                    and\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>MUT<\/jats:italic>\n                    <\/jats:sup>\n                    stratified posttransplant survival in Ven\u2010HMA treated patients with ND\u2010AML.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70480","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T12:14:31Z","timestamp":1787487271000},"page":"2746-2757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Older Age,\n                    <scp>\n                      <i>STAG2<\/i>\n                      ,\n                    <\/scp>\n                    and\n                    <scp>\n                      <i>DNMT3A<\/i>\n                    <\/scp>\n                    Mutations Predict Superior Posttransplant Survival in Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Hypomethylating Agents"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8914-6849","authenticated-orcid":false,"given":"Momna","family":"Warraich","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-4270","authenticated-orcid":false,"given":"Sudhesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota 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