{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:26Z","timestamp":1791812786787,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This multicenter, randomized, open\u2010label, exploratory Phase 2 trial assessed SHR\u20102004, an anti\u2010FXI antibody, for venous thromboembolism (VTE) prevention in patients undergoing ovarian cancer surgery\u2014a population at particularly high thrombotic risk conducted at 25 sites in China. Patients with newly diagnosed Stage III\u2013IV or recurrent ovarian cancer scheduled for surgery were randomly assigned (1:1) to receive subcutaneous SHR\u20102004 (180\u2009mg on Day 1 and 120\u2009mg on Day 15) or enoxaparin\u2013rivaroxaban (subcutaneous enoxaparin 40\u2009mg once daily during hospitalization, followed by oral rivaroxaban 10\u2009mg once daily after discharge until Day 28). The primary efficacy outcome was the composite of VTE events within 28\u2009days. The primary safety outcome was major bleeding (MB) or clinically relevant nonmajor bleeding (CRNMB) from first dose to 28\u2009days. Between February 19, 2024 and September 17, 2024, 198 patients received assigned treatment (90 with SHR\u20102004, 108 with enoxaparin\u2013rivaroxaban) and were included in the safety analysis. Among 181 patients who completed protocol\u2010mandated ultrasonography, VTE occurred in 11 (12.6%) patients in the SHR\u20102004 group and 19 (20.2%) in the enoxaparin\u2013rivaroxaban group (difference \u22128.4%, 95% CI \u221219.9 to 3.1) by Day 28. MB\/CRNMB rates were similar between groups (SHR\u20102004: 2\/90 [2.2%]; enoxaparin\u2013rivaroxaban: 2\/108 [1.9%]). In this study, SHR\u20102004 showed comparable efficacy to enoxaparin\u2013rivaroxaban for preventing postoperative VTE in patients undergoing ovarian cancer surgery, with a similar low risk of MB or CRNMB. The twice\u2010monthly dosing schedule offers a potential advantage over daily anticoagulation, supporting further investigation in adequately powered Phase 3 trials.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT06220123\n                  <\/jats:p>","DOI":"10.1002\/ajh.70481","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:50:41Z","timestamp":1787734241000},"page":"2776-2785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SHR<\/scp>\n                    \u20102004, a Humanized Monoclonal Antibody Targeting Factor\n                    <scp>XI<\/scp>\n                    , for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active\u2010Controlled Phase 2 Study"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-6487","authenticated-orcid":false,"given":"Guangyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6121-2400","authenticated-orcid":false,"given":"Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Hunan Tumor Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Shanxi Provincial Cancer Hospital  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-3291","authenticated-orcid":false,"given":"Keqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Hunan Tumor Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Jiangxi Cancer Hospital  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology The First Affiliated Hospital of Bengbu Medical University  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Yunnan Cancer Hospital  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology Shandong Cancer Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"An","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Fourth Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualei","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Affiliated Hospital of Jiangnan University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Jiangmen Central Hospital  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Anhui Provincial Cancer Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luwei","family":"Wei","sequence":"additional","affiliation":[{"name":"Gynecology, Liuzhou Worker's Hospital  Liuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujie","family":"Sheng","sequence":"additional","affiliation":[{"name":"Gynecology, The Third Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Guo","sequence":"additional","affiliation":[{"name":"Gynecology, Nanyang Central Hospital  Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Gynecology, Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Second Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-4395","authenticated-orcid":false,"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Gynecology, Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Ward V, Liaoning Cancer Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-8268","authenticated-orcid":false,"given":"Ping","family":"Zhan","sequence":"additional","affiliation":[{"name":"Gynecology, The Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Guo","sequence":"additional","affiliation":[{"name":"Jiangsu Hengrui Pharmaceuticals Co. 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