{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:56Z","timestamp":1791812756728,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) is a potentially curative strategy for acute myeloid leukemia (AML), but the impact of HLA disparity in the era of posttransplant cyclophosphamide (PTCy) and reduced\u2010toxicity conditioning remains unclear. We performed an EBMT registry study including 275 adult AML patients in first complete remission undergoing first allo\u2010HSCT between 2012 and 2023 using a uniform platform of treosulfan\u2010based conditioning and PTCy. Among them, 206 received haploidentical grafts and 69 underwent 9\/10 mismatched unrelated donor (MMUD) transplantation. Median follow\u2010up was 2.5\u2009years. At 2\u2009years, overall survival was 73.1% after haploidentical transplantation and 71.6% after MMUD transplantation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.96). Leukemia\u2010free survival at 1\u2009year was 66.3% and 65.2%, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.76). Relapse incidence (17.1% vs. 18.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.84) and nonrelapse mortality (16.6% vs. 16.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.86) were comparable between groups. Rates of Grade II\u2013IV and Grade III\u2013IV acute GVHD were similar, whereas chronic GVHD was higher after haploidentical transplantation (36.4% vs. 12.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), without differences in extensive forms. In multivariable analyses, donor type was not associated with overall survival, leukemia\u2010free survival, relapse incidence, or nonrelapse mortality. Increasing age adversely affected outcomes, while Karnofsky performance status \u2265\u200990 and reduced\u2010intensity conditioning were associated with improved survival. These findings suggest that, within a treosulfan\u2013PTCy platform, major transplant outcomes are comparable between donor types, although haploidentical transplantation was associated with a higher incidence of chronic GVHD.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70483","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:21:33Z","timestamp":1787397693000},"page":"2736-2745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitigating\n                    <scp>HLA<\/scp>\n                    Disparity in\n                    <scp>AML<\/scp>\n                    Transplantation: Comparable Outcomes After Haploidentical and 9\/10 Mismatched Unrelated Donor Transplantation With Treosulfan and\n                    <scp>PTCy<\/scp>"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-4170","authenticated-orcid":false,"given":"Daniele","family":"Avenoso","sequence":"first","affiliation":[{"name":"Unit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Science University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-9028","authenticated-orcid":false,"given":"Mirko","family":"Farina","sequence":"additional","affiliation":[{"name":"Unit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Science University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-130X","authenticated-orcid":false,"given":"Michele","family":"Malagola","sequence":"additional","affiliation":[{"name":"Unit of Blood Diseases and Bone Marrow Transplantation, Department of Clinical and Experimental Science University of Brescia, ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-8104","authenticated-orcid":false,"given":"Yves","family":"Chalandon","sequence":"additional","affiliation":[{"name":"Service D'hematologie, Departement d'Oncologie, and Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Saporiti","sequence":"additional","affiliation":[{"name":"BMT Unit, Hematology Division Fondazione IRCCS\u2014Ca' Granda OMP  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Imovilli","sequence":"additional","affiliation":[{"name":"Haematology Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-8140","authenticated-orcid":false,"given":"Enrico","family":"Derenzini","sequence":"additional","affiliation":[{"name":"Oncohematology Division European Institute of Oncology, IRCCS  Milan Italy"},{"name":"Department of Health Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9664-9067","authenticated-orcid":false,"given":"Peter","family":"Remenyi","sequence":"additional","affiliation":[{"name":"Del\u2010Pesti Centrumkorhaz  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3987-419X","authenticated-orcid":false,"given":"Massimo","family":"Martino","sequence":"additional","affiliation":[{"name":"Grande Ospedale Metropolitano Bianchi Melacrino Morelli\u2014Centro Unico Trapianti A. Neri  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"Itala\u2010Remes","sequence":"additional","affiliation":[{"name":"Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Fanin","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Universitaria Friuli Centrale  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-9447","authenticated-orcid":false,"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation&amp;Therapie Cellulaire  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-5308","authenticated-orcid":false,"given":"Desiree","family":"Kunadt","sequence":"additional","affiliation":[{"name":"University Hospital TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arancha Bermudez","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Marques Valdecilla\u2010IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-900X","authenticated-orcid":false,"given":"Franca","family":"Fagioli","sequence":"additional","affiliation":[{"name":"Ospedale Infantile Regina Margherita, University of Turin  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schroeder","sequence":"additional","affiliation":[{"name":"University Hospital, Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cavattoni","sequence":"additional","affiliation":[{"name":"Hospital San Maurizio  Bolzano 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Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-0123","authenticated-orcid":false,"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Hospital Scientific Institute  Milano 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