{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:26Z","timestamp":1791812786815,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The prognostic relevance of multiple myeloma (MM)\u2010defined high\u2010risk (HR) cytogenetic abnormalities in AL amyloidosis is incompletely defined. We retrospectively evaluated 517 newly diagnosed AL amyloidosis patients seen at Mayo Clinic between 2012 and 2021 who had baseline plasma cell FISH. HR cytogenetics were defined as\n                    <jats:italic>t<\/jats:italic>\n                    (4;14),\n                    <jats:italic>t<\/jats:italic>\n                    (14;16),\n                    <jats:italic>t<\/jats:italic>\n                    (14;20), del(17p), or 1q gain\/amplification (+1q). HR abnormalities were identified in 151 patients (29%); +1q accounted for most HR cases (122\/151, 81%). Compared with standard\u2010risk (SR), patients harboring +1q demonstrated a greater clonal disease burden, including higher dFLC and bone marrow plasma cells, greater intact immunoglobulin secretion, higher plasma cell proliferative index, and enrichment for modified SLiM\u2010CRAB features. Hematologic and organ response patterns of +1q patients were generally comparable to SR patients, whereas non\u20101q HR patients had a higher proportion of early hematologic responses. Patients harboring +1q demonstrated significantly inferior overall survival (OS) compared with both non\u20101q HR patients and SR patients (median OS 57\u2009months vs. not reached vs. 120\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). In multivariable piecewise Cox analysis, the adverse prognostic impact of +1q was most evident beyond 24\u2009months from diagnosis (HR 2.89, 95% CI 1.64\u20135.09,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas non\u20101q HR lesions were not independently prognostic. These findings suggest that +1q identifies a biologically distinct AL amyloidosis subset characterized by plasma cell\u2013dominant features and inferior long\u2010term disease control. In contrast, other MM\u2010defined HR cytogenetic abnormalities appear to have limited prognostic relevance in AL amyloidosis.\n                  <\/jats:p>","DOI":"10.1002\/ajh.70484","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:03:37Z","timestamp":1787634217000},"page":"2766-2775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chromosome 1q Gain Defines a Plasma Cell\u2013Dominant Adverse\u2010Risk Subtype in\n                    <scp>AL<\/scp>\n                    Amyloidosis With Inferior Long\u2010Term Survival"],"prefix":"10.1002","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2179-3963","authenticated-orcid":false,"given":"Tamer","family":"Hellou","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota 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