{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:14:13Z","timestamp":1760188453062},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,8,8]],"date-time":"2001-08-08T00:00:00Z","timestamp":997228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abnormal growth in Down syndrome (DS) is reflected by variable reduction in size and simplification in form of many physical traits. This study aimed to compare the thickness of enamel and dentine in deciduous and permanent mandibular incisor teeth between DS and non\u2010DS individuals and to clarify how these tissues contribute to altered tooth size in DS. Sample groups comprised 61 mandibular incisors (29 permanent and 32 deciduous) from DS individuals and 55 mandibular incisors (29 permanent and 26 deciduous) from non\u2010DS individuals. Maximum mesiodistal and labiolingual crown dimensions were measured initially, then the crowns were sectioned midsagittally and photographed using a stereomicroscope. Linear measurements of enamel and dentine thickness were obtained on the labial and lingual surfaces of the crowns, together with enamel and dentine\u2013pulp areas and lengths of the dentino\u2010enamel junction. Reduced permanent crown size in DS was associated with a reduction in both enamel and dentine thickness. After adjustments were made for tooth size, DS permanent incisors had significantly thinner enamel than non\u2010DS permanent teeth. The DS permanent teeth also exhibited significant differences in shape and greater variability in dimensions than the non\u2010DS permanent teeth. Crown dimensions of deciduous incisors were similar in size or larger in DS compared with non\u2010DS deciduous teeth. Enamel and dentine thicknesses of the deciduous teeth were similar in DS and non\u2010DS individuals. The findings indicate that growth retardation in DS reduces both enamel and dentine deposition in the permanent incisors but not in the earlier\u2010forming deciduous predecessors. The results are also consistent with the concept of amplified developmental instability for dental traits in DS. Am. J. Hum. Biol. 13:690\u2013698, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajhb.1107","type":"journal-article","created":{"date-parts":[[2004,11,14]],"date-time":"2004-11-14T12:35:42Z","timestamp":1100435742000},"page":"690-698","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Down syndrome on the dimensions of dental crowns and tissues"],"prefix":"10.1002","volume":"13","author":[{"given":"Emma","family":"Bell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules","family":"Kieser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345910700070801"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913129709021944"},{"key":"e_1_2_1_4_1","first-page":"537","article-title":"Mesiodistal crown dimensions of permanent and deciduous teeth in Down syndrome","volume":"59","author":"Barden HS","year":"1980","journal-title":"Hum Biol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014468400007181"},{"key":"e_1_2_1_6_1","first-page":"241","article-title":"The oral manifestations of trisomy G1 (Down syndrome)","volume":"7","author":"Cohen MM","year":"1971","journal-title":"Birth Defects: Original Article Series"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345650440011601"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92784-6"},{"key":"e_1_2_1_9_1","first-page":"257","volume-title":"Dental morphology and evolution","author":"Dahlberg AA","year":"1971"},{"key":"e_1_2_1_10_1","volume-title":"Statistical methods for medical and biological students","author":"Dahlberg G","year":"1940"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(93)90076-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420420403"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180307"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811092991903"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1999.00223.x"},{"key":"e_1_2_1_16_1","volume-title":"Cranial morphology in Down's syndrome. A comparative roentgencephalometric study in adult males","author":"Kisling E","year":"1966"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240563"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/314260a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1961.0212"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.9.1.92"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345570360011501"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240070"},{"key":"e_1_2_1_23_1","first-page":"467","article-title":"Dental organ formation: a chronological and topographic sequence","volume":"42","author":"Nery EB","year":"1975","journal-title":"J Dent Child"},{"key":"e_1_2_1_24_1","first-page":"173","article-title":"Comparison of cell cycle time in normal and trisomic cells","volume":"23","author":"Paton GR","year":"1974","journal-title":"Humangenetik"},{"key":"e_1_2_1_25_1","first-page":"167","article-title":"Modification of tooth size and shape in Down's syndrome","volume":"188","author":"Peretz B","year":"1996","journal-title":"J Anat"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(97)00034-4"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1998.19340529.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345760550041501"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)02172-7"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1975.tb00632.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140206"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(83)90123-1"},{"key":"e_1_2_1_33_1","first-page":"159","article-title":"Tooth morphology in Down's syndrome: evidence for retardation in growth","volume":"27","author":"Townsend GC","year":"1983","journal-title":"J Ment Defic Res"},{"key":"e_1_2_1_34_1","unstructured":"ZilbermanU.2000.Factors affecting tooth development and evolution: a radiographic study [doctoral dissertation]. Jerusalem: The Hebrew University of Jerusalem. p68\u201385."}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.1107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.1107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:37:29Z","timestamp":1700419049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.1107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,8]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1002\/ajhb.1107"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.1107","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,8]]}}}