{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:25:39Z","timestamp":1761056739957},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acid Phosphatase locus 1 (ACP1) is a polymorphic enzyme controlled by a locus on chromosome 2 with three common codominant alleles: *A, *B, and *C. ACP1 shows two major isoforms, F and S. The ratio of their concentration differs markedly among genotypes. Two functions have been proposed for the enzyme: flavin\u2010mononucleotide phosphatase and tyrosine phosphatase activity. An association between ACP1 polymorphism and past malarial morbidity in Sardinia and the Po Valley has been described. Genetic polymorphisms could contribute to natural resistance or susceptibility to the disease. On the other hand, malaria pressure may select for genes that increase susceptibility to common diseases of modern civilization. Thus, the association between ACP1 and malaria in Sardinia in the light of recent understanding of the function of ACP1 and the molecular basis of malaria pathophysiology, especially aspects of the structure of band 3 protein (B3P) and the role of cytokines have been revisited. There is a significant negative correlation between ACP1 S isoform concentration, directly related to the ACP1*C allele, and past malarial morbidity in Sardinia. Populations subjected in the past to a heavy malarial burden show, at present, a lower concentration of the S isoform compared to a nearby malaria\u2010free population, suggesting that genotypes with high S isoform concentration have been subjected to negative selection in a malarial environment. Correlation analysis and analysis of the joint G\u20106\u2010PD\/ACP1 distribution suggest that the relationship between past endemic malaria and the S isoform has not been mediated by glucose\u20106\u2010phosphate dehydrogenase (G\u20106\u2010PD) deficiency, thus pointing to a direct effect of malaria on ACP1. Am. J. Hum. Biol. 13:753\u2013760, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajhb.1121","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T22:20:22Z","timestamp":1031696422000},"page":"753-760","source":"Crossref","is-referenced-by-count":4,"title":["ACP1 and human adaptability: Association with past malarial morbidity in the Sardinian population"],"prefix":"10.1002","volume":"13","author":[{"given":"E.","family":"Bottini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Palmarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lucarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Bottini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Pathophysiology of hemolysis in glucose\u20106\u2010phosphate dehydrogenase deficiency","volume":"27","author":"Arese P","year":"1990","journal-title":"Sem Hematol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000075685"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(86)80456-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199902)108:2<241::AID-AJPA9>3.0.CO;2-Z"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210290"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3969.409"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00061.x"},{"key":"e_1_2_1_9_1","first-page":"365","article-title":"Roles of TNF in malaria and other parasitic infections","volume":"56","author":"Clark IA","year":"1992","journal-title":"Immunol Ser"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00502609"},{"key":"e_1_2_1_11_1","unstructured":"DissingJ.1993.Human \u201cred cell\u201d acid phosphatase (ACP1): genetic catalytic and molecular properties[doctoral dissertation]. 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