{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:56Z","timestamp":1772118296057,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,26]],"date-time":"2007-12-26T00:00:00Z","timestamp":1198627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Research strongly suggests that lower overall adiposity and higher central adiposity are independent risk factors for premenopausal breast cancer in the general population. We aimed to test the possibility that these factors may contribute to familial risk of premenopausal breast cancer. A convenience sample of healthy women, ages 25\u201349, was recruited to yield three study groups: (1) Women with first\u2010degree family histories of premenopausal breast cancer, operationally defined as being diagnosed prior to age 50 (Group FH &lt; 50, <jats:italic>n<\/jats:italic> = 39); (2) Women with first\u2010degree family histories of postmenopausal breast cancer, operationally defined as being diagnosed at age 50 or after (Group FH \u2265 50, <jats:italic>n<\/jats:italic> = 33); and (3) Women without a history of breast cancer in first\u2010degree relatives (Group FH\u2212, <jats:italic>n<\/jats:italic> = 132). Multinomial logistic regression analyses, including possible confounders, waist circumference, and BMI, revealed a lower BMI among FH &lt; 50 compared to either FH\u2212 (OR = 0.72; 95% CI = 0.59\u20130.87), or FH \u2265 50 women (OR = 0.75; 95% CI = 0.60\u20130.95), and higher waist circumferences in FH &lt; 50 compared to either FH\u2212 (OR = 1.15; 95% CI = 1.06\u20131.25), or FH \u2265 50 women (OR = 1.16; 95% CI = 1.05\u20131.28). No group differences were seen for waist skinfold measures. These results support the possibility that differences in patterns of adiposity may contribute to familial risk of premenopausal breast cancer, and suggest the importance of conducting large scale, population\u2010based studies of the link between body size characteristics and familial breast cancer risk. Am. J. Hum. Biol., 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajhb.20700","type":"journal-article","created":{"date-parts":[[2007,12,26]],"date-time":"2007-12-26T19:21:59Z","timestamp":1198696919000},"page":"355-358","source":"Crossref","is-referenced-by-count":3,"title":["Higher levels of central adiposity in healthy premenopausal women with family histories of premenopausal breast cancer"],"prefix":"10.1002","volume":"20","author":[{"given":"Lucia","family":"Dettenborn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D.","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana H.","family":"Bovbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209879"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06524-2"},{"key":"e_1_2_1_4_1","first-page":"245","article-title":"Sex hormones and adipose tissue distribution in premenopausal cigarette smokers","volume":"16","author":"Daniel M","year":"1992","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_1_5_1","first-page":"753","article-title":"Fat distribution in relation to age, degree of obesity, smoking habits, parity and estrogen use: A cross\u2010sectional study in 11,825 Dutch women participating in the DOM\u2010project","volume":"14","author":"den Tonkelaar I","year":"1990","journal-title":"Int J Obes"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.07.004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789X.2003.00108.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.4.683"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199801)105:1<9::AID-AJPA2>3.0.CO;2-T"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.11.1358"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35420"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00102-7"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.04.025"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930501)71:9<2764::AID-CNCR2820710913>3.0.CO;2-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90168-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.6.514"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050776"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.20700","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.20700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T22:15:06Z","timestamp":1700000106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.20700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,26]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/ajhb.20700"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.20700","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,26]]}}}