{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:57:30Z","timestamp":1791651450319,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the occurrence and intra\u2010allelic variability of the T<jats:sub>\u201013910<\/jats:sub> variant located upstream of the lactase gene in 965 individuals from 20 different locations of Italy and Greece. The T<jats:sub>\u201013910<\/jats:sub> frequency ranges from 0.072 (Sardinia) to 0.237 (North\u2010East Italy), with a statistically significant difference between North\u2010East Italians and other Italian populations. The comparison of the lactose tolerance predicted by T<jats:sub>\u201013910<\/jats:sub> and that assessed by other studies using physiological tests shows a one\u2010way statistically significant discrepancy that could be due to sampling differences. However, the possible role of other genetic factors underlying lactase persistence is worth exploring. The time of the most recent common ancestor and departures from neutrality of the T<jats:sub>\u201013910<\/jats:sub> allele were assessed using three microsatellite loci. Time estimates were found to be congruent with the appearance of dairy farming in Southern Europe and the occurrence of a single introgression event. Robust signals of selection can be observed in North\u2010East Italy only. We discuss the possible role of cultural traits and genetic history in determining these observed micro\u2010evolutionary patterns. Am. J. Hum. Biol. 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajhb.20851","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T17:54:43Z","timestamp":1230054883000},"page":"217-219","source":"Crossref","is-referenced-by-count":14,"title":["Tracing the distribution and evolution of lactase persistence in Southern Europe through the study of the T<sub>\u201013910<\/sub> variant"],"prefix":"10.1002","volume":"21","author":[{"given":"Paolo","family":"Anagnostou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Battaggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Coia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Capelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Pettener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Destro\u2010Bisol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donata","family":"Luiselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/9781400853113"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1263"},{"key":"e_1_2_1_4_1","first-page":"3","article-title":"The genetic history of Italy: a male prespective","volume":"85","author":"Capelli C","year":"2007","journal-title":"J Anthropol Sci"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/ajcn\/45.4.748","article-title":"Primary adult lactose malabsorption in Italy: regional differences in prevalence and relationship to lactose intolerance and milk consumption","volume":"45","author":"Cavalli\u2010Sforza LL","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-1322-z"},{"key":"e_1_2_1_7_1","first-page":"179","article-title":"Italian isolates today: geographic and linguistic factors shaping human biodiversity","volume":"86","author":"Destro\u2010Bisol G","year":"2008","journal-title":"J Anthropol Sci"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-7903(03)00016-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","DOI":"10.1515\/9781503621534","volume-title":"Coevolution: genes, culture and human diversity","author":"Durham W","year":"1991"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0620-8_1"},{"key":"e_1_2_1_12_1","first-page":"59","article-title":"History and geography of human Y\u2010chromosome in Europe: a SNP perspective","volume":"86","author":"Francalacci P","year":"2008","journal-title":"J Anthropol Sci"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200503000-00018"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164411"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1988.tb01098.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091740"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02233204"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/158.2.865"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.20851","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.20851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:36:19Z","timestamp":1697672179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.20851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,23]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/ajhb.20851"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.20851","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,23]]}}}