{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:33Z","timestamp":1787241993475,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T00:00:00Z","timestamp":1248825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Positive selection for inherited mutations in breast and ovarian cancer predisposing genes,\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    , may contribute to the high frequency of\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutations among the Ashkenazi Jewish population. Impact of\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutations on fertility has not been generally explored in epidemiologic studies. There are reports of distorted sex ratios in\n                    <jats:italic>BRCA<\/jats:italic>\n                    carrier families but these findings have been attributed to bias. We investigated the effect of\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutations on female fertility and offspring sex ratio in a study of 260 Ashkenazi Jewish women with ovarian cancer and 331 controls, unselected for age or family history of the disease. Pregnancy success was similar for 96 mutation carrier (0.84) and 164 noncarrier cases (0.87) and controls (0.83). After adjusting for covariates, there were no significant differences between\n                    <jats:italic>BRCA<\/jats:italic>\n                    carrier and noncarrier cases and controls with regards to fertility, despite lower pregnancy rates among all cases compared to controls (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0049). Male\/female sex ratios were significantly lower among offspring of carriers (0.71) than offspring of noncarriers (0.95) or those of the controls (0.99). Comparisons among the three groups yielded statistically significant distortion against males among the offspring of known and obligate\n                    <jats:italic>BRCA<\/jats:italic>\n                    carriers compared to noncarriers (OR = 0.74, 95% CI:0.55\u20130.99) and controls (OR = 0.71, 95% CI:0.54\u20130.94). In conclusion, we did not find evidence for an effect of\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutations on female fertility. We found a significant excess of females among the offspring of female carriers of\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutations. Potential contribution of observed sex ratio distortions to positive selection for\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutations may warrant further investigation. Am. J. Hum. Biol., 2010. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajhb.20978","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T14:47:43Z","timestamp":1248878863000},"page":"201-205","source":"Crossref","is-referenced-by-count":50,"title":["Impact of\n                    <i>BRCA<\/i>\n                    mutations on female fertility and offspring sex ratio"],"prefix":"10.1002","volume":"22","author":[{"given":"Roxana","family":"Moslehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Lessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201156"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.4.339"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.7.929"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.027722"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610887104"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.6.687"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.02.037"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/302313"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.9.719"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.156.3774.477"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000202"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-9102-z"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2544-b"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/302853"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-188"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-492-0_20"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0295-152"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-185"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-202"},{"key":"e_1_2_1_21_1","first-page":"1013","article-title":"Population genetics of BRCA1 and BRCA2","volume":"60","author":"Szabo CI","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800018"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msh214"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.20978","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.20978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T08:27:53Z","timestamp":1700555273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.20978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,29]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/ajhb.20978"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.20978","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,29]]}}}