{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:09:15Z","timestamp":1761743355828},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T00:00:00Z","timestamp":1271116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malaria endemicity in Southwest Iberia afforded conditions for an increase of sickle cell disease (SCD), which in the region follows a clinal pattern toward the south, where foci of high prevalence were found. SCD distribution is associated with specific geographical areas, and therefore, its introduction into Iberia may be related to the migration of different populations. We have analyzed the variation of uniparental markers in Portuguese populations with high frequency of SCD\u2014Coruche, Pias, and Alcacer do Sal\u2014to evaluate if their present\u2010day pattern of neutral diversity could provide evidence about people inhabiting the area over different time periods. Two hundred and eighty\u2010five individuals were sampled in Coruche, Pias, and Alcacer do Sal. All were analyzed for the control region of mitochondrial DNA (mtDNA); males were additionally examined for Y\u2010chromosome markers. Results were then compared with data from other Portuguese and non\u2010Portuguese populations. In Coruche, the genetic profile was similar to the profile usually found in Portugal. In Alcacer do Sal, the frequency of sub\u2010Saharan mtDNA L lineages was the highest ever reported (22%) in Europe. In Pias, mtDNA diversity revealed higher frequencies of Mediterranean haplogroups I, J, and T than usually found in surrounding populations. The presence of Sub\u2010Saharan maternal lineages in Alcacer do Sal is likely associated with the influx of African slaves between the 15th and 19th centuries, whereas in Pias, the Mediterranean influence might be traced to ancient contacts with Greeks, Phoenicians, and Carthaginians, who established important trading networks in southern Iberia. Am. J. Hum. Biol. 22:588\u2013595, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajhb.21049","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T18:27:26Z","timestamp":1271183246000},"page":"588-595","source":"Crossref","is-referenced-by-count":7,"title":["Genetic characterization of uniparental lineages in populations from Southwest Iberia with past malaria endemicity"],"prefix":"10.1002","volume":"22","author":[{"given":"V\u00e2nia","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Gusm\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Jo\u00e3o Prata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/512822"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-31789-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8817.2005.00221.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1995.tb01606.x"},{"key":"e_1_2_6_7_1","unstructured":"CruzI LucasI RosendoMT.2001. Mem\u00f3rias do instituto de Malariologia de \u00c1guas de Moura: da luta anti\u2010pal\u00fadica ao museu: C\u00e2mara Municipal de Palmela CEVDI; Instituto Nacional de Sa\u00fade Dr. Ricardo Jorge."},{"key":"e_1_2_6_8_1","volume-title":"Prehistoric Europe: an illustrated history","author":"Cunliffe B","year":"1998"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.03067.x"},{"key":"e_1_2_6_10_1","volume-title":"Passado Proto\u2010Hist\u00f3rico e Romano","author":"Fabi\u00e3o C","year":"1992"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsigss.2007.10.081"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7172008"},{"key":"e_1_2_6_13_1","unstructured":"LahonD.1999. O negro no cora\u00e7\u00e3o do imp\u00e9rio. Uma mem\u00f3ria a resgatar\u2014s\u00e9culos XV\u2010XIX Colec\u00e7\u00e3o Entreculturas."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.07.049"},{"key":"e_1_2_6_15_1","first-page":"891","article-title":"Importation route of the sickle cell trait into Portugal: contribution of molecular epidemiology","volume":"64","author":"Lavinha J","year":"1992","journal-title":"Hum Biol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2008.00478.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.3.235"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291165"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2000.6460491.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/316890"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/344348"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5494.1155"},{"key":"e_1_2_6_23_1","volume-title":"The slave trade\u2014the history of the Atlantic slave trade","author":"Thomas H","year":"1998"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1660"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.21049","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.21049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:25:51Z","timestamp":1698715551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.21049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,19]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1002\/ajhb.21049"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.21049","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,19]]}}}