{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:34Z","timestamp":1786976854058,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Biomarkers of inflammation, including C\u2010reactive protein (CRP) and \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010acid glycoprotein (AGP), have tremendous potential in anthropological, public health, and nutrition research as objective indicators of acute infection; however, their usage is limited by the lack of widely agreed upon, reliable cutpoints to define infection. We assessed the sensitivity and specificity of CRP and AGP for identifying acute infectious disease (ID) episodes among children in the Kilimanjaro region of Tanzania.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data were available from 43 3\u2010 to 5\u2010year\u2010old children. CRP and AGP were measured in capillary whole dried blood spots (DBS). Two\u2010week morbidity history interviews with children's primary caregivers were used to detect recent episodes of acute ID. Specimens and morbidity history interviews were collected from each child on one (\n                      <jats:italic>n<\/jats:italic>\n                      = 13) or two (\n                      <jats:italic>n<\/jats:italic>\n                      = 30) occasions for 73 paired interviews and specimens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We evaluated CRP and AGP for identifying acute infection (report of fever, diarrhea, or vomiting in the last week): CRP \u2265 1.1 mg\/l had sensitivity of 57.14% and specificity of 86.44%; AGP \u2265 0.76 g\/l had sensitivity of 57.14% and specificity of 72.41%. The combined definition (AGP \u2265 0.76 g\/l or CRP \u2265 1.1 mg\/l) had sensitivity of 71.43% and specificity of 70.69%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Among children in Kilimanjaro, Tanzania, assessed in whole blood stored as DBS, AGP \u2265 0.76 g\/l or CRP \u2265 1.1 mg\/l provided the best definition of acute infection. Whether this definition is appropriate for use in other populations remains to be determined. Am. J. Hum. Biol., 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.22261","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T08:35:33Z","timestamp":1331541333000},"page":"565-568","source":"Crossref","is-referenced-by-count":32,"title":["Sensitivity and specificity of C\u2010reactive protein and \u03b1\n                    <sub>1<\/sub>\n                    \u2010acid glycoprotein for episodes of acute infection among children in kilimanjaro, tanzania"],"prefix":"10.1002","volume":"24","author":[{"given":"Katherine","family":"Wander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Brindle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"O'connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2010.09.014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/ajcn\/67.6.1237","article-title":"Hyporetinolemia, illness symptoms, and acute phase protein response in pregnant women with and without night blindness","volume":"67","author":"Christian P","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.504159"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/58.2.192"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.2.434"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(00)00153-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.12.1835"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.029488"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20831"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.174367"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2000225"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/clinchem\/20.10.1255","article-title":"Statistical quality control and routine data processing for radioimmunoassays and immunoradismetric assays","volume":"20","author":"Rodbard D","year":"1974","journal-title":"Clin Chem"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(89)90010-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116336"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20839"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/clinchem\/44.6.1358","article-title":"Rapid automated high sensitivity enzyme immunoassay of C\u2010reactive protein","volume":"44","author":"Wilkins J","year":"1998","journal-title":"Clin Chem"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.22261","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.22261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:32:06Z","timestamp":1697031126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.22261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/ajhb.22261"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.22261","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,12]]}}}