{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:46:32Z","timestamp":1791308792514,"version":"4.3.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Many chronic diseases, including certain cancers, may originate through variations in the supply of nutrients to the fetus. These variations change gene expression and permanently set the structure and function of the body, a process known as programming. Fetal nutrition depends on the mother's metabolism and nutritional reserves, and on the placenta's ability to transfer nutrients from mother to baby. In this study, we examine how colorectal cancer is related to maternal and placental characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We ascertained 275 cases of colorectal cancer among the 20,431 people in the Helsinki Birth Cohort, who were born during 1924\u20131944 and whose body size at birth was recorded, together with the shape and size of the placenta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hazard ratios for colorectal cancer increased as the placental surface became longer and more oval. The hazard ratio was 2.3 (95% CI 1.2\u20134.7) among people in whom the difference between the length and breadth of the surface exceeded 6 cm, compared with those in whom there was no difference. Colorectal cancer was unrelated to other placental measurements or to body size at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An oval placental surface at birth is associated with later colorectal cancer. The shape of the placental surface is determined by events at around 8\u201312 weeks gestation. We speculate that, if the spiral arteries open prematurely, the surface becomes more oval and the fetus is at risk of oxidative damage at a time when the colon is differentiating. Am. J. Hum. Biol. 25:566\u2013568, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.22409","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T13:52:39Z","timestamp":1370872359000},"page":"566-568","source":"Crossref","is-referenced-by-count":43,"title":["The shape of the placental surface at birth and colorectal cancer in later life"],"prefix":"10.1002","volume":"25","author":[{"given":"David J. P.","family":"Barker","sequence":"first","affiliation":[{"name":"Heart Research Center, Oregon Health and Science University Portland Oregon"},{"name":"MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital  United Kingdom"},{"name":"Chair of Fetal Programming King Saud University  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Osmond","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital  United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent L.","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Heart Research Center, Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Kajantie","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Prevention National Institute for Health and Welfare Helsinki Finland"},{"name":"Hospital for Children and Adolescents Helsinki University Central Hospital and University of Helsinki  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan G.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Prevention National Institute for Health and Welfare Helsinki Finland"},{"name":"Department of General Practice and Primary Health Care University of Helsinki  Finland"},{"name":"Vasa Central Hospital  Finland"},{"name":"Folkh\u00e4lsan Research Centre Helsinki Finland"},{"name":"Unit of General Practice Helsinki University Central Hospital  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2011.11.014"},{"key":"e_1_2_5_3_1","first-page":"5","volume-title":"The placenta and human developmental programming","author":"Barker DJP","year":"2011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044160"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.6941"},{"key":"e_1_2_5_6_1","first-page":"161","volume-title":"The placenta and human developmental programming","author":"Burton GJ","year":"2011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604918"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.3109S"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.06.011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.060475"},{"key":"e_1_2_5_11_1","first-page":"935","article-title":"Self\u2010reported birth weight and subsequent risk of colorectal cancer","volume":"11","author":"Sandhu MS","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869409098430"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.886"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009534"},{"key":"e_1_2_5_15_1","first-page":"95","article-title":"The role of epidermal growth factor receptor in the mechanism and treatment of colorectal cancer","volume":"11","author":"Yarom N","year":"2011","journal-title":"Discov Med"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.22409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.22409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.22409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:28:43Z","timestamp":1696541323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.22409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,10]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/ajhb.22409"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.22409","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,10]]}}}