{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:03Z","timestamp":1788871863546,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Spanish Ministry of Science","award":["PSI2008-0448\/PSIC"],"award-info":[{"award-number":["PSI2008-0448\/PSIC"]}]},{"name":"This work was supported by the Valencia innovation and research program for student researchers (VALi+d)","award":["ACIF\/2011\/075"],"award-info":[{"award-number":["ACIF\/2011\/075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>High intrauterine testosterone (T) levels seem to play a role in the development of autism spectrum disorders (ASDs), but their role in anorexia nervosa (AN) is controversial. Parents with masculinized 2D:4D ratios, a marker of the organizational effects of T, may have other relevant biological characteristics, in particular exposing their offspring to high T levels in the prenatal environment. This would increase the likelihood of their offspring developing these disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present study examined whether parents of offspring with AN (\n                      <jats:italic>n<\/jats:italic>\n                      =34; mean age= 51) and ASD (\n                      <jats:italic>n<\/jats:italic>\n                      =36; mean age=45) differ from control parents (\n                      <jats:italic>n<\/jats:italic>\n                      =40; mean age=43) in 2D:4D ratio, as well as by salivary T levels and its relationships.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results revealed that AN and ASD parents (fathers and mothers) have masculinized 2D:4D ratios of the right hand compared to control parents. However, the difference compared to controls was larger in the ASD than the AN group. Furthermore, current salivary T levels were negatively related to the 2D:4D ratio in ASD and AN parents only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data partially support the view of high prenatal masculinization as a potential intermediate phenotype to the development of these disorders in their offspring. Am. J. Hum. Biol. 26:863\u2013866, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.22597","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T04:08:19Z","timestamp":1406779699000},"page":"863-866","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal testosterone of progenitors could be involved in the etiology of both anorexia nervosa and autism spectrum disorders of their offspring"],"prefix":"10.1002","volume":"26","author":[{"given":"\u00c1ngel","family":"Romero\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Psychobiology Department University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Moya\u2010Albiol","sequence":"additional","affiliation":[{"name":"Psychobiology Department University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diagnostic and statistical manual of mental disorders, 4th ed.\u2014text revision (DSM\u2010IV\u2010TR)","author":"Association AP","year":"2000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/eog.12.54"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0041"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.47"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206002118"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1998.1492"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21054"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705006653"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.22495"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500161"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.05.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00181.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.11.3000"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2009.02065.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2010.07.024"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08030362"},{"key":"e_1_2_6_18_1","first-page":"264","article-title":"The 2D:4D ratio and its relationship with other androgenisation parameters in parents of individuals with autism spectrum disorders","volume":"29","author":"Romero\u2010Mart\u00ednez A","year":"2013","journal-title":"Ann Psychol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054713482685"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20736"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.22597","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.22597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:08:29Z","timestamp":1696565309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.22597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/ajhb.22597"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.22597","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}