{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:55:26Z","timestamp":1789080926235,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The main objective of this study was to evaluate the effect of the <jats:italic>ADIPOQ<\/jats:italic> rs2241766, <jats:italic>LEP<\/jats:italic> rs7799039, and <jats:italic>FTO<\/jats:italic> rs9939609 polymorphisms on the birth weight status of Brazilian infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted in southern Brazil. Large for gestational age (LGA) newborns (<jats:italic>n<\/jats:italic>\u2009=\u2009105), and the same number of small for gestational age\/adequate for gestational age newborns, were included. Genotyping of the rs2241766, rs7799039, and rs9939609 polymorphisms was done by PCR\u2010RFLP analysis. Logistic regression was used to investigate the association between LGA newborns and the presence of the polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infants carrying the GG genotype of the rs7799039 polymorphism were 2.12 times more likely to be born LGA than those carrying the GA\u2009+\u2009AA genotypes (95% CI: 1.17\u20133.83). These results did not change substantially after adjusting for potential confounding variables (OR\u2009=\u20091.98; 95% CI 1.05\u20133.73) and adjustment for the three polymorphisms (OR\u2009=\u20091.98; 95% CI 1.05\u20103.74). Regarding the <jats:italic>ADIPOQ<\/jats:italic> polymorphism, newborns carrying the TG or GG genotype were 1.88 times more likely to be born LGA than those carrying the TT genotype, although this difference was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.082). No association was found between the <jats:italic>FTO<\/jats:italic> gene polymorphism and newborn weight status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that the GG genotype of the <jats:italic>LEP<\/jats:italic> polymorphism rs7799039 is a risk factor for LGA infants. The exact role and mechanism of action of the GG genotype of this polymorphism in weight status control remain to be elucidated, and more studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.22893","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T06:07:24Z","timestamp":1468044444000},"source":"Crossref","is-referenced-by-count":9,"title":["Association of <i>ADIPOQ<\/i>, <i>LEP<\/i>, and <i>FTO<\/i> gene polymorphisms with large for gestational age infants"],"prefix":"10.1002","volume":"29","author":[{"given":"Caroline","family":"Kroll","sequence":"first","affiliation":[{"name":"Post\u2010Graduation Program in Health and Environment University of Joinville Region Joinville Santa Catarina 89.219\u2010710 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silmara S.B.S.","family":"Mastroeni","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alberta, Population Health Intervention Research Unit Edmonton Alberta T6G 2T4 Canada"},{"name":"Department of Physical Education University of Joinville Region Joinville Santa Catarina 89.219\u2010710 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Veugelers","sequence":"additional","affiliation":[{"name":"School of Public Health University of Alberta, Population Health Intervention Research Unit Edmonton Alberta T6G 2T4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-8866","authenticated-orcid":false,"given":"Marco F.","family":"Mastroeni","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Health and Environment University of Joinville Region Joinville Santa Catarina 89.219\u2010710 Brazil"},{"name":"School of Public Health University of Alberta, Population Health Intervention Research Unit Edmonton Alberta T6G 2T4 Canada"},{"name":"Department of Biological Sciences University of Joinville Region Joinville Santa Catarina 89.219\u2010710 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0324"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-871738"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.050"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-14-34"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0499-0"},{"key":"e_1_2_6_9_1","volume-title":"Common variant within the FTO gene, rs9939609, obesity and type 2 diabetes in population of Karachi, Pakistan. 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