{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:56:58Z","timestamp":1765727818759,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["090375"],"award-info":[{"award-number":["090375"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2017,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Low birthweight is associated with a decreased risk of childhood leukemia and an increased risk of both cardiovascular disease and all\u2010cause mortality in adult life. Possible biological mediators include systemic innate immunity and inflammation. We tested the hypothesis that birthweight was inversely associated with serum high sensitivity C reactive protein assay (hsCRP), a measure of both innate immunity and systemic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on birthweight and current anthropometric measures along with a range of exposures were collected at 1 and 3 years of age in a population\u2010based cohort study of young children living in Havana, Cuba. A total of 986 children aged 3\u2010years\u2010old provided blood samples that were analyzed for serum hsCRP levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly 49% of children had detectable hsCRP levels in their serum. Lower birthweight was linearly associated with the natural log of hsCRP levels (beta coefficient \u22120.70 mg\u00a0L<jats:sup>\u22121<\/jats:sup> per kg increase in birthweight, 95% CI: \u22121.34 to \u22120.06). This was attenuated but still present after adjustment for the child's sex and municipality (\u22120.65 mg\u00a0L<jats:sup>\u22121<\/jats:sup> per kg birthweight; 95% CI: \u22121.38 to +0.08). There were no associations between growth from birth or anthropometric measures at 3 years and systemic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Birthweight was inversely associated with serum hsCRP levels in children aged 3 years living in Cuba. These observations provide a potential mechanism that is present at the age of 3 years to explain the association between low birthweight and both decreased childhood leukemia and increased cardiovascular disease in adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.22936","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T14:16:40Z","timestamp":1479478600000},"source":"Crossref","is-referenced-by-count":3,"title":["The association of low birth weight with serum C reactive protein in 3\u2010year\u2010old children living in Cuba: A population\u2010based prospective study"],"prefix":"10.1002","volume":"29","author":[{"given":"Silvia","family":"Josefina Venero\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermes","family":"Fundora\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Batista\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Su\u00e1rez\u2010Medina","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza","family":"de la C. Mora\u2010Faife","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ileana","family":"del Valle\u2010Infante","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liem","family":"G\u00f3mez\u2010Marrero","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Higiene, Epidemiolog\u00eda y Microbiolog\u00eda Infanta No 1158 e\/ Llin\u00e1s y Clavel C\u00f3digo Postal 10300 La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Britton","sequence":"additional","affiliation":[{"name":"Nottingham Biomedical Research Unit, Division of Epidemiology and Public Health University of Nottingham, Clinical Sciences Building, City Hospital Nottingham NG5 1PB United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Nottingham Biomedical Research Unit, Division of Epidemiology and Public Health University of Nottingham, Clinical Sciences Building, City Hospital Nottingham NG5 1PB United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"HINASIC (Historia Natural de la Sibilancia en Cuba\/Natural History of Wheezing in Cuba) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9023"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-71"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.02.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400025200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.9.1294"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2011.12.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00312-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl175"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7255.199"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:30:3:261"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.30"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12293"},{"key":"e_1_2_6_14_1","first-page":"545","article-title":"Association of serum C\u2010reactive protein and indices of body fat distribution and overweight in Mexican American children","volume":"95","author":"Gillum R.","year":"2003","journal-title":"Journal of National Medical Association"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708473"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh287"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1244"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.3116"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2009.1795"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:24:2:163"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2011.10.006"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601762"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2007.12.007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1158\/1055-9965.1057.13.6","article-title":"Birth weight and other risk factors for acute leukemia in the Jerusalem Perinatal Study Cohort","volume":"13","author":"Paltiel O.","year":"2004","journal-title":"Cancer Epidemiology, Biomarkers, Prevention"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.8.731"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000125690.80303.A8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq267"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000118277.41584.63"},{"key":"e_1_2_6_30_1","article-title":"C\u2010reactive protein is essential for innate resistance to pneumococcal infection","author":"Simons J.","year":"2014","journal-title":"Immunology."},{"key":"e_1_2_6_31_1","unstructured":"Spinreact high sensitivity CRP assay.2016. Available at:http:\/\/wwwspinreactcom\/files\/Inserts\/SERIE_SPINTECH_(TKB)\/Turbilatex\/TKCRP__4-1_CAL_liof_2012pdf(accessed 4\/7\/2016)"},{"key":"e_1_2_6_32_1","unstructured":"Stata Corp.2016. Available at:http:\/\/www.stata.com\/manuals14\/u.pdf(accessed 4\/7\/2016)."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-14-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7283"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn105"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct143"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq103"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.22936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.22936","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.22936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajhb.22936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.22936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T09:03:50Z","timestamp":1693731830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.22936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5,6]]}},"alternative-id":["10.1002\/ajhb.22936"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.22936","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"type":"print","value":"1042-0533"},{"type":"electronic","value":"1520-6300"}],"subject":[],"published":{"date-parts":[[2016,11,18]]},"article-number":"e22936"}}