{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:26Z","timestamp":1786976846111,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000992","name":"braf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2017,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Skin pigmentation is a polygenic trait showing wide phenotypic variations among global populations. While numerous pigmentation genes have been identified to be under positive selection among European and East populations, genes contributing to phenotypic variation in skin pigmentation within and among South Asian populations are still poorly understood. The present study uses data from the Phase 3 of the 1000 genomes project focusing on two South Asian populations\u2014GIH (Gujarati Indian from Houston, Texas) and ITU (Indian Telugu from UK), so as to decode the genetic architecture involved in adaptation to ultraviolet radiation in South Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Statistical tests included were (1) tests to identify deviations of the Site Frequency Spectrum (SFS) from neutral expectations (Tajima's\n                      <jats:italic>D<\/jats:italic>\n                      , Fay and Wu's\n                      <jats:italic>H<\/jats:italic>\n                      and Fu and Li's\n                      <jats:italic>D<\/jats:italic>\n                      * and\n                      <jats:italic>F<\/jats:italic>\n                      *), (2) tests focused on the identification of high\u2010frequency haplotypes with extended linkage disequilibrium (iHS and Rsb), and (3) tests based on genetic differentiation between populations (LSBL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two pigmentation genes fall in the top 1% for at least one statistic in the GIH population, 5 of which (\n                      <jats:italic>LYST, OCA2, SLC24A5, SLC45A2<\/jats:italic>\n                      , and\n                      <jats:italic>TYR<\/jats:italic>\n                      ) have been previously associated with normal variation in skin, hair, or eye color. In comparison, 17 genes fall in the top 1% for at least one statistic in the ITU population. Twelve loci which are identified as outliers in the ITU scan were also identified in the GIH population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These results suggest that selection may have affected these loci broadly across the region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.23012","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:57:22Z","timestamp":1493081842000},"source":"Crossref","is-referenced-by-count":11,"title":["Identifying signatures of positive selection in pigmentation genes in two South Asian populations"],"prefix":"10.1002","volume":"29","author":[{"given":"Manjari","family":"Jonnalagadda","sequence":"first","affiliation":[{"name":"Symbiosis School for Liberal Arts (SSLA) Symbiosis International University (SIU) Pune 411014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Bharti","sequence":"additional","affiliation":[{"name":"HPC\u2010MBA Group, Centre for Development of Advanced Computing Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatish","family":"Patil","sequence":"additional","affiliation":[{"name":"HPC\u2010MBA Group, Centre for Development of Advanced Computing Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Ozarkar","sequence":"additional","affiliation":[{"name":"Department of Anthropology Savitribai Phule Pune University Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunitha Manjari","family":"K","sequence":"additional","affiliation":[{"name":"HPC\u2010MBA Group, Centre for Development of Advanced Computing Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Joshi","sequence":"additional","affiliation":[{"name":"HPC\u2010MBA Group, Centre for Development of Advanced Computing Pune 411007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Norton","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.10.016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-8-74"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.GR-1733RR"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/382262a0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513197113"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003912"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss207"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00293"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048294"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.21079"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000500"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr330"},{"key":"e_1_2_5_14_1","first-page":"190","article-title":"A spectrophotometric skin colour survey among four Indian castes and tribes","volume":"54","author":"Das S. 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