{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:26:42Z","timestamp":1764174402224,"version":"3.41.2"},"reference-count":99,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["BCS\u20100136761"],"award-info":[{"award-number":["BCS\u20100136761"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2017,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Humans\u2014and several other apes\u2014exhibit a unique pattern of post\u2010natal adrenal maturation; however, the causes and consequences of variation in adrenal development are not well understood. In this study, we examine developmental and age\u2010related maturation of the adrenal gland (measured via dehydroepiandrosterone\u2010sulfate [DHEA\u2010S]) for potential life\u2010history associations with growth and mucosal immunity in a rural population of immune\u2010challenged Bolivian juveniles and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Salivary DHEA\u2010S, anthropometrics, and salivary mucosal immunity (secretory IgA [sIgA]) were measured in 171 males and females, aged 8\u201023.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Males with greater energy (i.e. fat) stores showed higher DHEA\u2010S levels. Controlling for age and energetic condition (to control for phenotypic correlation), higher DHEA\u2010S was associated with higher mucosal immunity (sIgA) among both males and females. Higher DHEA\u2010S levels were positively associated with growth (i.e. height and strength) in males.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In accordance with predictions derived from life\u2010history theory, males with higher energy stores secrete more adrenal androgens. This suggests that adrenal maturation is costly and subject to constraints; that is, only males with sufficient reserves will invest in accelerated adrenal maturation. Further, DHEA\u2010S appears to have a measureable influence on immunocompetence in adolescent males and females; therefore, deficits in DHEA\u2010S may have important consequences for health and maturation during this period. Adrenal maturation is an important, but understudied component of human growth and development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.23025","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T12:10:40Z","timestamp":1498565440000},"source":"Crossref","is-referenced-by-count":13,"title":["Adrenal maturation, nutritional status, and mucosal immunity in Bolivian youth"],"prefix":"10.1002","volume":"29","author":[{"given":"Carolyn R.","family":"Hodges\u2010Simeon","sequence":"first","affiliation":[{"name":"Department of Anthropology Boston University Boston Massachusetts 02215"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Prall","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of California Los Angeles California 90095"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-9865","authenticated-orcid":false,"given":"Aaron D.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of California Santa Barbara California 93106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gurven","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of California Santa Barbara California 93106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.C.","family":"Gaulin","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of California Santa Barbara California 93106"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/9780691207278"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0002-8223(21)01175-5","article-title":"Dehydroepiandrosterone sulfate, cholesterol, hemoglobin, and anthropometric measures related to growth in male adolescents","volume":"91","author":"Arquitt A. B.","year":"1991","journal-title":"Journal of the American Dietetic Association"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2007.01067.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.4.7402"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21092"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460.2016.1189963"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.23128"},{"volume-title":"Patterns of human growth","year":"1999","author":"Bogin B.","key":"e_1_2_8_11_1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02319.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20528"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21111"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20661"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90431-H"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-4-717"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.12.022"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.2.433"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200413"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X09000016"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00840-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00002-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02256.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.10152"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2012.693199"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1580409"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10764-014-9749-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700034644"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(99)00013-X"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20600"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.2.196"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2005.3380"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861550"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.12.016"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2007.10.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/evan.1360020303"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.evolhumbehav.2015.01.002"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.12.6341"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1410.050"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6505(2000)9:4<156::AID-EVAN5>3.0.CO;2-7"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00278.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922007903"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918272"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.4.1001"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.123-128.2001"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/504326"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20644"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(98)00007-5"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1086\/376508"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072460"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2012.03.003"},{"volume-title":"Anthropometric standardization reference manual","year":"1988","author":"Lohman T. G.","key":"e_1_2_8_54_1"},{"key":"e_1_2_8_55_1","first-page":"S125","article-title":"Dehydroepiandrosterone metabolism","volume":"150","author":"Longscope C.","year":"1996","journal-title":"Journal of Endocrinology"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.91.1.61"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10398"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eov033"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20831"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40750-015-0030-8"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02161-2"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20419"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-1-57"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031848"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-3-551"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb17398.x-i1"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.9.7863"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.1.41"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2002.0182"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22387"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.22724"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0743-4_2"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2011.0829"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.8.1539"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.11.3936"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-5-850"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.12.006"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)01038-2"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802328"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2008.1177"},{"key":"e_1_2_8_81_1","first-page":"709","article-title":"Skinfold equations for estimation of body fatness in children and youth","volume":"60","author":"Slaughter M. H.","year":"1988","journal-title":"Human Biology"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-5-932"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.03.008"},{"volume-title":"The evolution of life histories","year":"1992","author":"Stearns S. C.","key":"e_1_2_8_84_1"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330280507"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-1229(05)80024-8"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/116.10.1977"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0145553200023191"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510001"},{"key":"e_1_2_8_90_1","first-page":"893","article-title":"Salivary secretory IgA, pH, flow rates, Mutans streptococci and Candida in children with rampant caries","volume":"39","author":"Thaweboon S.","year":"2008","journal-title":"South East Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.22747"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20997"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21074"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.18.2243"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/29.10.1752"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330920410"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20510"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530600569877"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330710409"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.02.010"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajhb.23025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.23025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajhb.23025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/ajhb.23025","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.23025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:40:02Z","timestamp":1696588802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.23025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":99,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9,10]]}},"alternative-id":["10.1002\/ajhb.23025"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.23025","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"type":"print","value":"1042-0533"},{"type":"electronic","value":"1520-6300"}],"subject":[],"published":{"date-parts":[[2017,6,27]]},"article-number":"e23025"}}