{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:49:15Z","timestamp":1753861755830,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Time\u2010to\u2010Pregnancy (TTP) is an epidemiological tool to assess couple fecundity. The finger digit ratio (2D:4D) has been suggested as a marker of androgen exposure in utero. Maternal, paternal, or couple\u2010mediated factors related to fecundity may also have an effect on androgen exposure during pregnancy. We aimed to investigate the association between TTP, infertility, or use of Assisted Reproductive Technologies (ART) and offspring 2D:4D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 673 mother\u2010child pairs were collected from questionnaires in the Maternal\u2010Infant Research on Environmental Chemicals (MIREC) study across 10 cities in Canada. The mean maternal age was 33.4 years (SD 4.7), with a median gestational age of 12.1 weeks (SD 1.3), at the time of recruitment. Our study included 338 girls and 335 boys, and the mean age of the children at follow\u2010up was 3.5 years (SD 1.0). TTP was assessed through questionnaires during the first trimester of pregnancy. Digital photographs of both hands were taken in a follow\u2010up study to calculate the children's 2D:4D (2\u20135 years). <jats:sc>anova<\/jats:sc>, <jats:italic>t<\/jats:italic> tests, and multiple linear regression analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Boys had significantly lower mean 2D:4Ds (0.936\u2009\u00b10.041 in right hand, 0.936\u2009\u00b10.040 in left hand) compared to girls (0.948\u2009\u00b10.038 in right hand, 0.945\u2009\u00b10.038 in left hand). The mean 2D:4D did not differ according to TTP, infertility, or use of ART. The only factors associated with the child's 2D:4D were the child's age and maternal 2D:4D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study does not support an association between TTP, infertility, or use of ART and children's 2D:4D.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.23176","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T14:58:08Z","timestamp":1539788288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Time\u2010to\u2010pregnancy and offspring finger\u2010length ratio (2D:4D)"],"prefix":"10.1002","volume":"30","author":[{"given":"Mahvash","family":"Shere","sequence":"first","affiliation":[{"name":"School of Medicine Queen's University  Kingston Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tye E.","family":"Arbuckle","sequence":"additional","affiliation":[{"name":"Targeted Epidemiology and Biomonitoring Section, Environmental Health Science and Research Bureau Healthy Environments and Consumer Safety Branch  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Monnier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University Health Centre  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Fraser","sequence":"additional","affiliation":[{"name":"Sainte\u2010Justine University Hospital Research Centre University of Montreal  Montreal Canada"},{"name":"Department of Obstetrics and Gynecology University of Sherbrooke  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-8279","authenticated-orcid":false,"given":"Maria P.","family":"Velez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Reproductive Endocrinology and 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