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This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV\u2010exposure on late\u2010life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred and forty nine subjects were examined for vitamin D<jats:sub>2<\/jats:sub>and D<jats:sub>3<\/jats:sub>(HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Solar irradiance over the first 90\u2009days postconception correlated positively with late\u2010life vitamin D<jats:sub>3<\/jats:sub>(<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= .0140;<jats:italic>P<\/jats:italic>= .0082;<jats:italic>\u03b2<\/jats:italic>= .1075), but not vitamin D<jats:sub>2<\/jats:sub>levels. It also correlated positively with female adult height (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= .170;<jats:italic>P<\/jats:italic>= .0103;<jats:italic>\u03b2<\/jats:italic>= .1291) and negatively with the occurrence of female osteoporosis (<jats:italic>P<\/jats:italic>= .0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (<jats:italic>P<\/jats:italic>= .0009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased solar irradiance\/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.23272","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T12:15:01Z","timestamp":1560255301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early lifecycle UV\u2010exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0788-5177","authenticated-orcid":false,"given":"Mark","family":"Lucock","sequence":"first","affiliation":[{"name":"School of Environmental &amp; Life Sciences University of Newcastle Ourimbah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohith","family":"Thota","sequence":"additional","affiliation":[{"name":"Nutraceuticals Research Group University of Newcastle Ourimbah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manohar","family":"Garg","sequence":"additional","affiliation":[{"name":"Nutraceuticals Research Group University of Newcastle Ourimbah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; 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