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We aimed to assess the frequency of CMV infection and its relationship with age among EBV seropositive individuals in an Indigenous Amazonian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report concentrations of CMV and EBV antibodies in dried blood spot samples collected from 157 EBV positive Shuar participants aged 15\u201386\u2009years (60.5% female) to assess CMV infection rate. We used logistic and linear regression models to examine associations among CMV, EBV, and age, adjusting for sex, geographic region, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly two\u2010thirds (63.1%) of EBV seropositive participants were also CMV seropositive. A 1\u2010year increase in age was associated with 3.4% higher odds of CMV infection (OR [95% CI]: 1.034 [1.009\u20131.064], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012), but CMV antibody concentration was not significantly associated with age or EBV antibody concentration among co\u2010infected individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Herpesvirus\u2010related immunosenescence may be important to understanding chronic disease risk among Shuar. Future studies should further explore the role of co\u2010infection in shaping age\u2010related changes in immune function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.23713","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T14:20:14Z","timestamp":1639664414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Age\u2010related<\/scp> patterns of cytomegalovirus antibodies accompanying <scp>Epstein\u2010Barr<\/scp> virus <scp>co\u2010infection<\/scp>"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-8704","authenticated-orcid":false,"given":"Tyler M.","family":"Barrett","sequence":"first","affiliation":[{"name":"Department of Evolutionary Anthropology Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Liebert","sequence":"additional","affiliation":[{"name":"Department of Anthropology Northern Arizona University  Flagstaff Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-3265","authenticated-orcid":false,"given":"Geeta N.","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Oregon  Eugene Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia G.","family":"Ridgeway\u2010Diaz","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia C.","family":"Madimenos","sequence":"additional","affiliation":[{"name":"Department of Anthropology Queens College, City University of New York  Flushing New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-9865","authenticated-orcid":false,"given":"Aaron D.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Anthropology Washington State University  Pullman WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-4117","authenticated-orcid":false,"given":"Samuel S.","family":"Urlacher","sequence":"additional","affiliation":[{"name":"Department of Anthropology Baylor University  Waco Texas USA"},{"name":"Child and Brain Development Program CIFAR  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence S.","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Oregon  Eugene Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Josh","family":"Snodgrass","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Oregon  Eugene Oregon USA"},{"name":"Center for Global Health University of Oregon  Eugene Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-017-9983-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.11.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21092"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-8-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix255"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/19485565.2016.1169396"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2012.759621"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.22296"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1353\/dem.2007.0038"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01262-06"},{"key":"e_1_2_9_14_1","unstructured":"Ridgeway\u2010Diaz J. G.(2011).Epstein\u2010Barr virus and psychosocial stress in the Shuar of Ecuadorian Amazon [Master's thesis University of Oregon]."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717522115"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460.2016.1192219"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.23713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajhb.23713","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.23713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:46:20Z","timestamp":1692639980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.23713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/ajhb.23713"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.23713","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"assertion":[{"value":"2021-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23713"}}