{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:47:28Z","timestamp":1780699648391,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2054\/19"],"award-info":[{"award-number":["2054\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To clarify the potential risk factors and etiology of low back pain (LBP)\u2010related disability, including structural changes of the spine (spinal scoliosis) and body composition components in a population with a high prevalence of LBP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, two self\u2010reported validated questionnaires were used to collect back pain and disability data in an ethnically homogeneous family\u2010based population sample (<jats:italic>N\u2009=<\/jats:italic>\u00a01078). The scoliosis angle of trunk rotation was measured by a scoliometer on three spinal levels while the patient was bent forward. Body composition parameters, including relative to weight (WT), fat, relative skeletal muscle mass (SMM\/WT), and total body water were determined by bioelectrical impedance analysis. Statistical analysis was conducted, accounting for the familial composition of the sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mixed multiple regression analyses with several LBP\u2010related phenotypes as dependent variables consistently showed significant independent associations with scoliosis and SMM\/WT, irrespective of other covariates. The odds ratios (OR)\/95% CI for scoliosis ranged between 1.40 (1.19\u20131.64) and 1.51 (1.27\u20131.80), and from 0.61(0.51\u20130.72), to 0.71(0.58\u20130.87) for SMM\/WT, depending on the LBP phenotype. The genetic components of the respective correlations between the LBP\u2010phenotypes and scoliosis or SMM\/WT were negligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The associations between LBP\u2010related conditions and postured scoliosis and SMM\/WT were consistent and significant and therefore may serve as markers in predicting the development of LBP\u2010related disability. We interpret the origin of these correlations as the evolutionary event due to the imperfect spine anatomy adaptation to a vertical posture resulting from a quick transition to bipedalism from a quadrupedal ancestor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.23757","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T15:48:50Z","timestamp":1652111330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Scoliosis and skeletal muscle mass are strongly associated with low back pain\u2010related disability in humans: An evolutionary anthropology point of view"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-9673","authenticated-orcid":false,"given":"Nader","family":"Tarabeih","sequence":"first","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Maale HaCarmel Mental Health Center, Affiliated to Rappaport Faculty of Medicine Technion, Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Masharawi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, The Stanley Steyer School of Health Professions, Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Shalata","sequence":"additional","affiliation":[{"name":"The Simon Winter Institute for Human Genetics, Bnai Zion Medical Center The Ruth and Bruce Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orabi","family":"Higla","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kalinkovich","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Livshits","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2020.102769"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60610-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13013-016-0086-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43390-021-00384-6"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"33","article-title":"Pathogenesis of idiopathic scoliosis. 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