{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:48:02Z","timestamp":1783381682671,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Data concerning the association of vitamin D with metabolic disturbances in adolescents are contradictory. The aim of this study was to identify metabolic abnormalities in adolescents with 25\u2010hydroxyvitamin D (25[OH]D) deficiency and to determine informative indices for the early detection of these metabolic disturbances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional observational study including 90 adolescents aged 13\u201315\u2009years was carried out during the winter. Anthropometric measures were collected. Fasting blood samples were assessed for the following parameters: serum 25(OH)D, lipids, and glucose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of the study adolescents had low 25(OH)D concentration. The prevalence of 25(OH)D deficiency (&lt;12\u2009ng\/ml) and insufficiency (12\u201320\u2009ng\/ml) in adolescents was 34.4% and 55.6%, respectively. Among the metabolic disturbance, hypo\u2010high\u2010density lipoprotein cholesterolemia prevailed in the adolescents, while hypercholesterolemia, hypertriglyceridemia, and hyperglycemia were rare. 25(OH)D status showed an association with the metabolic score for insulin resistance (METS\u2010IR, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.40; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), high\u2010density lipoprotein cholesterol level (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.31; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003), atherogenic index of plasma (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.30; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) and body mass index (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.23, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.032). There were no significant correlations between 25(OH)D level and other lipid or glucose levels. The degree of hypovitaminosis D affects METS\u2010IR values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>25(OH)D deficiency in the studied adolescents had not yet manifested serious metabolic diseases. Of all the analyzed parameters, METS\u2010IR was most strongly associated with 25(OH)D level and can be considered a useful marker of early metabolic disturbances in adolescents with 25(OH)D deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.23802","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T17:06:05Z","timestamp":1663866365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of serum 25\u2010hydroxyvitamin D with metabolic disturbances in adolescents"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-4300","authenticated-orcid":false,"given":"Anastasiya M.","family":"Kaneva","sequence":"first","affiliation":[{"name":"Institute of Physiology of \u041a\u043emi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Komi SC UB RAS  Syktyvkar Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4804-6908","authenticated-orcid":false,"given":"Natalya N.","family":"Potolitsyna","sequence":"additional","affiliation":[{"name":"Institute of Physiology of \u041a\u043emi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Komi SC UB RAS  Syktyvkar Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-898X","authenticated-orcid":false,"given":"Evgeny R.","family":"Bojko","sequence":"additional","affiliation":[{"name":"Institute of Physiology of \u041a\u043emi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Komi SC UB RAS  Syktyvkar Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0883"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.139121"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.12.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13330"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb21323.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.02.014"},{"key":"e_1_2_10_8_1","first-page":"853","article-title":"Serum vitamin\u2010D predicts insulin resistance in individuals with prediabetes","volume":"138","author":"Dutta D.","year":"2013","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.01.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092413"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2013.11.023"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2018.04.004"},{"key":"e_1_2_10_13_1","volume-title":"Dietary reference intakes for calcium and vitamin D","author":"Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium","year":"2011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/children4090080"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2011.09.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0323-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.05.018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9070125"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.104158"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494814541593"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013001225"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes.2018.27.4.223"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.09.013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.224"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3146"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25738"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0213"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/495101"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83302-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092879"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2007.20.7.817"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101359"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.04.009"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.05.019"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0223"},{"key":"e_1_2_10_36_1","first-page":"1859","article-title":"Vitamin D deficiency enhances insulin resistance by promoting inflammation in type 2 diabetes","volume":"12","author":"Wang W.","year":"2019","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.12.016"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(13)71003-x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000846"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.11.017"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.873"}],"container-title":["American Journal of Human Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.23802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajhb.23802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajhb.23802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T08:09:41Z","timestamp":1692518981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajhb.23802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/ajhb.23802"],"URL":"https:\/\/doi.org\/10.1002\/ajhb.23802","archive":["Portico"],"relation":{},"ISSN":["1042-0533","1520-6300"],"issn-type":[{"value":"1042-0533","type":"print"},{"value":"1520-6300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,22]]},"assertion":[{"value":"2022-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23802"}}