{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:58Z","timestamp":1786976818133,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002943","name":"Departament d'Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chronic stress induces preclinical changes in the metabolic, cardiovascular, and immune systems. This phenomenon, known as allostatic load (AL), can impair executive functions (EF), which may be even more affected in individuals with excess weight due to their characteristic inflammatory state and cardiometabolic changes. Adverse childhood experiences (ACEs) contribute to AL and may influence executive functioning presumably via alterations within the hypothalamic\u2013pituitary axis, including epigenetic modifications. We assess the relationship between AL and EF in youth with and without excess weight, and the effect ACEs on executive functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred eighty\u2010two adolescents and young adults (85 with normal weight and 97 with overweight\/obesity; 10\u201321\u2009years) were recruited. The estimated AL index included the following: systolic and diastolic blood pressure, glycated hemoglobin, high\u2010 and low\u2010density lipoprotein cholesterol, triglycerides, high\u2010sensitivity C\u2010reactive protein, fibrinogen, and cortisol. ACEs were measured using the Juvenile Victimization Questionnaire. The neuropsychological evaluation included the assessment of inhibition, working memory, and cognitive flexibility processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AL was not significantly associated with executive functioning, and this relationship did not depend on body\u2010weight status. ACEs, available for 57 of 182 participants, were significantly associated with poorer executive functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study shows that AL is not associated with executive functioning in adolescents and young adults. Since the current sample was young, we hypothesize that a longer exposure to AL might be required for its negative effects to surface. Nevertheless, exposure to early adversity seems to be associated with poorer executive functioning in youth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.24089","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T03:03:32Z","timestamp":1714100612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Allostatic load, adverse childhood experiences, executive functions, and\n                    <scp>BMI<\/scp>\n                    status in adolescents and young adults"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8565-0966","authenticated-orcid":false,"given":"Anna","family":"Prunell\u2010Casta\u00f1\u00e9","sequence":"first","affiliation":[{"name":"Departament de Psicologia Cl\u00ednica i Psicobiologia, Facultat de Psicologia Universitat de Barcelona  Barcelona Spain"},{"name":"Institut de Neuroci\u00e8ncies Universitat de Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u Esplugues de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-8249","authenticated-orcid":false,"given":"Maite","family":"Garolera","sequence":"additional","affiliation":[{"name":"Brain, Cognition and Behavior: Clinical Research Hospital de Terrassa  Barcelona Spain"},{"name":"Neuropsychology Unit Hospital de Terrassa  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-9926","authenticated-orcid":false,"given":"Jonatan","family":"Ottino\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-1670","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Jurado","sequence":"additional","affiliation":[{"name":"Departament de Psicologia Cl\u00ednica i Psicobiologia, Facultat de Psicologia Universitat de Barcelona  Barcelona Spain"},{"name":"Institut de Neuroci\u00e8ncies Universitat de Barcelona  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u Esplugues de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220888"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00335"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.111050"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12501"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2012.00064.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104849"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105761"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2014.01.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-113011-143750"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.112578"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104605"},{"key":"e_1_2_10_13_1","volume-title":"STROOP, test de colores y palabras","author":"Golden C. 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