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Plasma proteomics is at the forefront of identifying biomarkers for various clinical conditions. We aimed to examine the association between plasma\u2010targeted proteomics involved in cardiovascular health and resting vagal\u2010related HRV parameters in children with overweight\/obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four children with overweight\/obesity (10.2\u2009\u00b1\u20091.1\u2009years old; 52% boys) participated in the study. Olink's technology was used to quantify 92 proteins involved in cardiovascular health. HRV was measured using a heart rate monitor (Polar RS800CX). Four resting vagal\u2010related HRV parameters were derived in time\u2010 and frequency\u2010domain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight proteins (KIM1, IgG Fc receptor II\u2010b, IDUA, BOC, IL1RL2, TNFRSF11A, VSIG2, and TF) were associated with at least one out of the four vagal\u2010related HRV parameters (<jats:italic>\u03b2<\/jats:italic> values ranging from \u22120.188 to 0.288; all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), while KIM1, IDUA, and BOC associated with \u2265 three vagal\u2010related HRV parameters. Multiple hypothesis testing corrections did not reach statistical significance (false discovery rate [FDR\u2009&gt;0.05]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Plasma\u2010targeted proteomics suggested novel biomarkers for resting vagal\u2010related HRV parameters in children with overweight\/obesity. Future studies using larger cohorts and longitudinal designs should confirm our findings and their potential clinical implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajhb.24113","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:59:50Z","timestamp":1718186390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight\/obesity"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-3129","authenticated-orcid":false,"given":"Abel","family":"Plaza\u2010Florido","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine University of California at Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Olvera\u2010Rojas","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-374X","authenticated-orcid":false,"given":"Juan M. A.","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Institute for Innovation &amp; Sustainable Food Chain Development, Department of Health Sciences Public University of Navarre  Pamplona Spain"},{"name":"Navarra Institute for Health Research IdiSNA  Pamplona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Radom\u2010Aizik","sequence":"additional","affiliation":[{"name":"Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine University of California at Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-1121","authenticated-orcid":false,"given":"Francisco B.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Faculty of Sport and Health Sciences University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020325"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"53","article-title":"Statistical estimates and transformed beta variables. 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