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Using autopsy data from the Chicago Infant Mortality Study, a majority African\u2010American case\u2013control study of deceased infants under 1\u2009year conducted 1993\u201396, we assessed differences in the weights of brain, thymus, kidneys, lungs, liver, spleen, total body, and four length anthropometry measures in SIDS\u2010diagnosed infants compared to controls. Using exact and coarsened matching, we ran Bayesian linear models with these anthropometry outcomes and repeated the analyses substituting the corresponding fitted allometrically\u2010scaled organ weight indices to account for body size. After detailed analysis and adjustment for potential confounders, we found that matched SIDS infants were generally bigger than controls, with higher mean brain, liver, spleen, thymus, lung, and total body weights, and higher mean head and chest circumference, crown\u2010heel, crown\u2010rump lengths. SIDS infants also had higher mean thymus, liver, spleen, lung and total body weight indices. The association with thymus weight was proportionately greater in magnitude than any other outcome measure and independent of body size. The results of these more detailed analyses are consistent with recent findings from other studies with differing racial compositions, and substantially confirm the primary organ sites for more detailed mechanistic research into the biological dysregulation contributing to underlying pathophysiology of SIDS.<\/jats:p>","DOI":"10.1002\/ajhb.24126","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T07:22:26Z","timestamp":1719991346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Organ weights and length anthropometry measures at autopsy for sudden infant death syndrome cases and other infant deaths in the Chicago infant mortality study"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-0005","authenticated-orcid":false,"given":"Josyf C.","family":"Mychaleckyj","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Normeshie","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern R.","family":"Hauck","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb37232.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v080.i01"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v076.i01"},{"issue":"11","key":"e_1_2_9_6_1","first-page":"1","article-title":"Infant mortality in the United States, 2021: Data from the period linked birth\/infant death file","volume":"72","author":"Ely D. 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