{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:07:54Z","timestamp":1787062074654,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007238","name":"Office of Women's Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inflammation is a marker of immune activation. Inflammation may have an effect on both ovarian function and luteal function, both essential to pregnancy. High inflammation may also signal dysregulated processes within the ovary, which could be in part measured through Anti\u2010M\u00fcllerian hormone, follicle\u2010stimulating hormone, and inhibin B levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the relationship between inflammation, measured by C\u2010reactive protein, and three biomarkers of ovarian function during the early follicular phase: Anti\u2010M\u00fcllerian hormone, follicle\u2010stimulating hormone, and inhibin B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Secondary cross\u2010sectional analysis of data and serum obtained in Time to Conceive, a prospective cohort study sample of 843 women attempting pregnancy in central North Carolina from 2008 to 2016. Participants were aged 30 and 44\u2009years, had no history of infertility, endometriosis, or polycystic ovarian syndrome, and were not currently breastfeeding. Serum samples were obtained on days 2, 3, or 4 of the menstrual cycle. C\u2010reactive protein (natural\u2010log transformed), Anti\u2010M\u00fcllerian hormone (natural\u2010log transformed), follicle\u2010stimulating hormone (natural\u2010log transformed), and inhibin B (untransformed) were measured in serum. Diminished ovarian reserve was examined dichotomously and defined as an Anti\u2010M\u00fcllerian hormone level below 0.7\u2009ng\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 703 participants with C\u2010reactive protein measured. In an adjusted linear regression model, a 20% increase in C\u2010reactive protein was associated with a 0.57\u2009pg\/mL decrease in inhibin B (95% CI: \u22120.84 to \u22120.29\u2009pg\/mL) and a 0.535% decrease in follicle\u2010stimulating hormone (95% CI: \u22121.01 to \u22120.06). Although there was not a significant relationship between Anti\u2010M\u00fcllerian hormone and C\u2010reactive protein, a 20% increase in C\u2010reactive protein was associated with a 0.87% increase in Anti\u2010M\u00fcllerian hormone (95% CI: \u22120.27 to 2.01). C\u2010reactive protein was not associated with the odds of diminished ovarian reserve in an adjusted logistic regression model (OR: 0.97, 95% CI: 0.77\u20131.20).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inflammation, as measured by C\u2010reactive protein, is associated with early follicular phase follicle\u2010stimulating hormone and inhibin B, although this is not true of AMH. Inflammation may exert an effect on ovarian function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.24196","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T01:04:53Z","timestamp":1733187893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammation and Ovarian Function in Reproductive\u2010Aged Women"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-5524","authenticated-orcid":false,"given":"Anneliese","family":"Long","sequence":"first","affiliation":[{"name":"Department of Anthropology University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Carolina Population Center University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Z.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5872-738X","authenticated-orcid":false,"given":"Amanda L.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Carolina Population Center University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Department of Nutrition, Gillings School of Global Public Health University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Jahnke","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences Epidemiology Branch  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin 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